Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00064519
Status:
COMPLETED
Last Update Posted:
2015-09-24
First Post:
2003-07-08
Brief Title:
Genetics of CRP in Families With Myocardial Infarction
Sponsor:
Medical College of Wisconsin
Organization:
Medical College of Wisconsin
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2015-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the genetics of C reactive protein in families with myocardial infarction
Detailed Description:
BACKGROUND
Coronary artery disease CAD and myocardial infarction MI are the leading causes of death in the Western world Numerous epidemiological studies have demonstrated the impact of various risk factors such as arterial hypertension hypercholesterolemia and diabetes mellitus While these risk factors are partly under genetic control a positive family history remains an additional independent predictor of CAD suggesting the presence of as yet unidentified susceptibility loci Given the enormous public health burden of CAD there is significant interest in identifying its specific genetic foundations As intensive experimental investigations continue the inflammatory component of the disease process leading to atherosclerosis evolves as a key aspect in the disease process Recent evidence demonstrates that systemic markers of inflammation such as C reactive protein CRP can predict those at high risk of coronary events CRP emerges with much attention as both a diagnostic marker and therapeutic target with serum levels determined to a significant extent by genetic factors
DESIGN NARRATIVE
To elucidate the genetic basis of the inflammatory component of myocardial infarction and the regulation of C reactive protein a gene function oriented evaluation of candidate genes will be conducted Therefore the specific aims are as follows 1 Identify positional candidate genes within regions identified for MI and CRP which are functionally related to inflammation and inflammatory processes Sequence variation in selected candidate genes will be identified 2 Evaluate the effect of these variants with regard to MI and CRP in two different ethnic populations a family set of European Caucasians and a population-based Hispanic family dataset The role of CRP will be evaluated as a predictor of cardiovascular events in the study populations Since clinical follow up data are available on both study populations the extent to which CRP contributes to an increased risk for cardiovascular events will be analyzed
Coronary artery disease CAD and myocardial infarction MI are the leading causes of death in the Western world Numerous epidemiological studies have demonstrated the impact of various risk factors such as arterial hypertension hypercholesterolemia and diabetes mellitus While these risk factors are partly under genetic control a positive family history remains an additional independent predictor of CAD suggesting the presence of as yet unidentified susceptibility loci Given the enormous public health burden of CAD there is significant interest in identifying its specific genetic foundations As intensive experimental investigations continue the inflammatory component of the disease process leading to atherosclerosis evolves as a key aspect in the disease process Recent evidence demonstrates that systemic markers of inflammation such as C reactive protein CRP can predict those at high risk of coronary events CRP emerges with much attention as both a diagnostic marker and therapeutic target with serum levels determined to a significant extent by genetic factors
DESIGN NARRATIVE
To elucidate the genetic basis of the inflammatory component of myocardial infarction and the regulation of C reactive protein a gene function oriented evaluation of candidate genes will be conducted Therefore the specific aims are as follows 1 Identify positional candidate genes within regions identified for MI and CRP which are functionally related to inflammation and inflammatory processes Sequence variation in selected candidate genes will be identified 2 Evaluate the effect of these variants with regard to MI and CRP in two different ethnic populations a family set of European Caucasians and a population-based Hispanic family dataset The role of CRP will be evaluated as a predictor of cardiovascular events in the study populations Since clinical follow up data are available on both study populations the extent to which CRP contributes to an increased risk for cardiovascular events will be analyzed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL074321 | NIH | None | httpsreporternihgovquickSearchR01HL074321 |