Ignite Creation Date:
2024-05-05 @ 11:31 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00064688
Status:
WITHDRAWN
Last Update Posted:
2015-09-10
First Post:
2003-07-10
Brief Title:
Genomic Dissection of a QTL Affecting the Lipid Profile
Sponsor:
Medical College of Wisconsin
Organization:
Medical College of Wisconsin
Study Overview
Official Title:
Genomic Dissection of a QTL Affecting the Lipid Profile
Status:
WITHDRAWN
Status Verified Date:
2015-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
This protocol was created to support work as part of an NIH-funded study
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To search for the genetic cause of the metabolic syndrome a lipid disorder that poses a major risk for coronary heart disease
Detailed Description:
BACKGROUND
The metabolic syndrome is a common disorder posing a significant major risk for coronary heart disease and early mortality in the Western hemisphere Central to its cardiovascular complications is the association of the syndrome with the specific abnormalities in plasma lipid and lipoprotein profiles including increased plasma triglycerides decreased HDL cholesterol and predominance of dense lipoprotein particles In search for the genetic etiology of this lipid disorder the investigators identified a quantitative trait locus QTL on human chromosome 7q36 strongly linked to variation in plasma lipid levels They hypothesize that this QTL contains genetic variants that contribute to alterations in biologic pathways underlying the genesis of the lipid disorder
DESIGN NARRATIVE
The study will search for the genetic cause of the metabolic syndrome a lipid disorder that poses a major risk for coronary heart disease The investigators have identified a quantitative trait locus QTL on human chromosome 7q36 strongly linked to variation in plasma lipid levels The investigators hypothesize that this QTL contains genetic variants that contribute to alterations in biologic pathways underlying the genesis of the lipid disorder To test for this hypothesis they propose a comprehensive approach utilizing established resources and expertise to identify the functional sequence variants within this QTL Specifically they will 1 identify single nucleotide polymorphisms SNPs and their haplotype and linkage disequilibrium structure across the entire QTL region 2 Analyze association of informative SNPs with plasma triglyceride levels LDL levels and lipoprotein density fractions using variance component linkagedisequilibrium analyses and 3 Identify potentially functional sequence variants in associated genes or genomic regions using Bayesian quantitative trait nucleotide analysis This comprehensive application of newly available genomic technologies novel statistical approaches the DNA and phenotypic information available and the consortium of expertise assembled behind this project will ensure the successful elucidation of the genetic etiology of this lipid disorder and consequently the development of effective means for prevention andor treatment of cardiovascular complications of the metabolic syndrome
The metabolic syndrome is a common disorder posing a significant major risk for coronary heart disease and early mortality in the Western hemisphere Central to its cardiovascular complications is the association of the syndrome with the specific abnormalities in plasma lipid and lipoprotein profiles including increased plasma triglycerides decreased HDL cholesterol and predominance of dense lipoprotein particles In search for the genetic etiology of this lipid disorder the investigators identified a quantitative trait locus QTL on human chromosome 7q36 strongly linked to variation in plasma lipid levels They hypothesize that this QTL contains genetic variants that contribute to alterations in biologic pathways underlying the genesis of the lipid disorder
DESIGN NARRATIVE
The study will search for the genetic cause of the metabolic syndrome a lipid disorder that poses a major risk for coronary heart disease The investigators have identified a quantitative trait locus QTL on human chromosome 7q36 strongly linked to variation in plasma lipid levels The investigators hypothesize that this QTL contains genetic variants that contribute to alterations in biologic pathways underlying the genesis of the lipid disorder To test for this hypothesis they propose a comprehensive approach utilizing established resources and expertise to identify the functional sequence variants within this QTL Specifically they will 1 identify single nucleotide polymorphisms SNPs and their haplotype and linkage disequilibrium structure across the entire QTL region 2 Analyze association of informative SNPs with plasma triglyceride levels LDL levels and lipoprotein density fractions using variance component linkagedisequilibrium analyses and 3 Identify potentially functional sequence variants in associated genes or genomic regions using Bayesian quantitative trait nucleotide analysis This comprehensive application of newly available genomic technologies novel statistical approaches the DNA and phenotypic information available and the consortium of expertise assembled behind this project will ensure the successful elucidation of the genetic etiology of this lipid disorder and consequently the development of effective means for prevention andor treatment of cardiovascular complications of the metabolic syndrome
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL074168 | NIH | None | httpsreporternihgovquickSearchR01HL074168 |