Ignite Creation Date:
2024-05-05 @ 10:53 PM
Last Modification Date:
2024-10-26 @ 10:25 AM
Study NCT ID:
NCT01209429
Status:
COMPLETED
Last Update Posted:
2011-09-13
First Post:
2010-09-24
Brief Title:
Importance of the GHIGF-1 Axis for Human Substrate and Energy Metabolism During Calorie Restriction
Sponsor:
University of Aarhus
Organization:
University of Aarhus
Study Overview
Official Title:
Importance of the GHIGF-1 Axis for Human Substrate and Energy Metabolism During Calorie Restriction
Status:
COMPLETED
Status Verified Date:
2011-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will investigate whether growth hormone is modulated by the enzyme SIRT1 and by that is stimulating lipolysis on expense of IGF-I production This is done in 10 healthy men on calorie restriction on 4 study days with fat and skeletal muscle biopsies
Detailed Description:
It has been shown that calorie restriction enhances the length of life in yeast worms fish and rodent Whether this elongation of life due to calorie restriction can be applied to humans is not known However it is a fact that calorie restriction will decrease the risk of developing metabolic disturbances such as diabetes hypertension and atherosclerosis
On the molecular level the specific relations are not fully understood This study will investigate the possible connection between SITR1 and the relation to the GHIGF-I axis and STAT5b in healthy men The participant will fast 42 and 12 hours respectively and have GH or placebo infusions The design is a classical 2x2 design and will be randomized
Knowledge of the interactions between calorie restriction SIRT1 STAT5b and the GHIGF-I axis will apply important information about the relations between aging energy metabolism and metabolic disturbances
On the molecular level the specific relations are not fully understood This study will investigate the possible connection between SITR1 and the relation to the GHIGF-I axis and STAT5b in healthy men The participant will fast 42 and 12 hours respectively and have GH or placebo infusions The design is a classical 2x2 design and will be randomized
Knowledge of the interactions between calorie restriction SIRT1 STAT5b and the GHIGF-I axis will apply important information about the relations between aging energy metabolism and metabolic disturbances
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None