Ignite Creation Date:
2024-05-05 @ 11:30 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00067418
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2003-08-18
Brief Title:
Light Scattering Spectroscopy to Determine Brain Tumors
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Spectroscopic Determination of Brain Tumor Cells
Status:
COMPLETED
Status Verified Date:
2004-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use light scattering spectroscopy LSS to analyze brain tissue removed from patients during brain surgery to determine if this new technology can be used to differentiate between normal and cancerous cells LSS focuses light on cells or tissues and the way that light is reflected back from the tissues provides information about the size of cells and the density of the cell nuclei the part of the cell that contains the genes
Patients between 18 and 75 years of age with a known or suspected brain tumor and patients with temporal lobe epilepsy that does not respond to medication may be eligible for this study Examination of tissue from patients with epilepsy will allow comparison of tumor and non-tumor brain cells All patients must require surgery to treat their condition
Participants will be admitted to the Clinical Center for 3 to 10 days for physical and neurological examinations blood and urine tests and other tests needed to prepare for surgery They will then undergo surgery A small amount of tissue removed during surgery for pathological review will be collected for use in this study
Half of the tissue will be examined using LSS to help determine the size of the cell and its nucleus Studies will be done to measure how many of the cells are actively dividing and which proteins are expressed more often in tumor cells compared with normal cells This information may shed light on how tumor cells are different from normal cells
Participants may be contacted for up to 3 years to follow their health status
Patients between 18 and 75 years of age with a known or suspected brain tumor and patients with temporal lobe epilepsy that does not respond to medication may be eligible for this study Examination of tissue from patients with epilepsy will allow comparison of tumor and non-tumor brain cells All patients must require surgery to treat their condition
Participants will be admitted to the Clinical Center for 3 to 10 days for physical and neurological examinations blood and urine tests and other tests needed to prepare for surgery They will then undergo surgery A small amount of tissue removed during surgery for pathological review will be collected for use in this study
Half of the tissue will be examined using LSS to help determine the size of the cell and its nucleus Studies will be done to measure how many of the cells are actively dividing and which proteins are expressed more often in tumor cells compared with normal cells This information may shed light on how tumor cells are different from normal cells
Participants may be contacted for up to 3 years to follow their health status
Detailed Description:
Optical spectroscopy for detection of brain tumors and tumor margins has been shown to be of use in distinguishing gliomas and metastatic tumor cells from surrounding white matter Optical spectroscopy has the potential to provide immediate and accurate diagnostic information about the nature and quantity of neoplastic cells in a minimally-or non-invasive fashion We propose to use a new method of optical spectroscopy polarized light-scattering spectroscopy LSS which permits discrimination of malignant cancer cells from normal brain cells by virtue of alterations in the cytoplasmic and nuclear ratios of these cells
Patients suspected of having or with prior biopsy proof of a WHO grade II-IV central nervous system CNS glial tumors those with metastatic brain tumor or patients with medically-refractory temporal lobe epilepsy with a presumed hippocampal source of seizures who are seen in the Surgical Neurology Branch NINDS will be considered for entry into this study Tissue samples of tumor or normal lateral temporal neocortex resected as part of standard care will be collected at surgery and utilized for research
Patients suspected of having or with prior biopsy proof of a WHO grade II-IV central nervous system CNS glial tumors those with metastatic brain tumor or patients with medically-refractory temporal lobe epilepsy with a presumed hippocampal source of seizures who are seen in the Surgical Neurology Branch NINDS will be considered for entry into this study Tissue samples of tumor or normal lateral temporal neocortex resected as part of standard care will be collected at surgery and utilized for research
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-N-0270 | None | None | None |