Ignite Creation Date:
2024-05-05 @ 11:30 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00063505
Status:
COMPLETED
Last Update Posted:
2014-04-24
First Post:
2003-06-30
Brief Title:
Genes of Hypertension in African Americans
Sponsor:
Medical College of Wisconsin
Organization:
Medical College of Wisconsin
Study Overview
Official Title:
Genes of Hypertension in African Americans
Status:
COMPLETED
Status Verified Date:
2014-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To identify genes contributing to hypertension in African Americans by focusing on the physiological pathways that determine arterial pressure
Detailed Description:
BACKGROUND
Since the mid 1990s the investigators have extensively characterized African Americans for phenotypes related to cardiovascular and renal function Based on recently completed genome scans they have identified several chromosomal regions likely to contain genes influencing hypertension-related phenotypes in hypertensive African American sib pairs For several phenotypes overlapping QTLs have also been identified in related studies in a genetically isolated French Canadian population andor in homologous chromosomal regions in the F2 cross of Dahl-salt sensitive x normotensive Brown Norway rats
DESIGN NARRATIVE
The investigators will extensively phenotype 500 hypertensive and 500 normotensive African American subjects to conduct a genetic association study using a single nucleotide polymorphism SNP genomic scan approach To achieve a clear separation of blood pressures from hypertensive subjects normotensive subjects will be selected from the lower third of the population-based blood pressure distribution Hypertensive BMI and age Inclusion of phenotypes is based on their relevance to the pathophysiology of hypertension and prior evidence of heritability Candidate genes for SNP analysis will be selected within chromosomal regions of two quantitative trait loci QTLs that they have previously demonstrated to be linked to hypertension-related phenotypes--a QTL for body mass index on chromosome 1 and a QTL for microalbuminuria on chromosome 18 SNP analyses will be carried out in 15 percent of the genes within each of these QTLs and genes will be selected on the basis of their relevance to hypertension including documented sequence conservation for blood pressure related QTLs with rat or mouse The final goal of the project is to determine if distinct clusters of blood pressure related phenotypes can be identified that will permit stratification of hypertensive individuals into distinct subgroups to facilitate the analysis of the genetic determinants of hypertension andor provide mechanistic leads to genes contributing to these traits
Since the mid 1990s the investigators have extensively characterized African Americans for phenotypes related to cardiovascular and renal function Based on recently completed genome scans they have identified several chromosomal regions likely to contain genes influencing hypertension-related phenotypes in hypertensive African American sib pairs For several phenotypes overlapping QTLs have also been identified in related studies in a genetically isolated French Canadian population andor in homologous chromosomal regions in the F2 cross of Dahl-salt sensitive x normotensive Brown Norway rats
DESIGN NARRATIVE
The investigators will extensively phenotype 500 hypertensive and 500 normotensive African American subjects to conduct a genetic association study using a single nucleotide polymorphism SNP genomic scan approach To achieve a clear separation of blood pressures from hypertensive subjects normotensive subjects will be selected from the lower third of the population-based blood pressure distribution Hypertensive BMI and age Inclusion of phenotypes is based on their relevance to the pathophysiology of hypertension and prior evidence of heritability Candidate genes for SNP analysis will be selected within chromosomal regions of two quantitative trait loci QTLs that they have previously demonstrated to be linked to hypertension-related phenotypes--a QTL for body mass index on chromosome 1 and a QTL for microalbuminuria on chromosome 18 SNP analyses will be carried out in 15 percent of the genes within each of these QTLs and genes will be selected on the basis of their relevance to hypertension including documented sequence conservation for blood pressure related QTLs with rat or mouse The final goal of the project is to determine if distinct clusters of blood pressure related phenotypes can be identified that will permit stratification of hypertensive individuals into distinct subgroups to facilitate the analysis of the genetic determinants of hypertension andor provide mechanistic leads to genes contributing to these traits
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL070111 | NIH | None | httpsreporternihgovquickSearchR01HL070111 |