Ignite Creation Date:
2024-05-05 @ 11:30 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00063440
Status:
COMPLETED
Last Update Posted:
2013-02-08
First Post:
2003-06-26
Brief Title:
Epidemiology of Carotid IMT Progression in MESA - Ancillary Study
Sponsor:
Tufts Medical Center
Organization:
Tufts Medical Center
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2013-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine the factors associated with progression of sub-clinical atherosclerosis and to evaluate the associations between the progression of sub-clinical atherosclerosis and the development of clinically manifest atherosclerosis
Detailed Description:
BACKGROUND
Cardiovascular disease remains the leading cause of death in the United States and one of the leading causes of morbidity New technology recently has allowed the non-invasive investigation of the extent of atherosclerosis in different vascular beds Unfortunately the clinical implications and significance of this new technology have not yet been fully examined nor has the interrelationship between these various measurements of clinical and sub-clinical atherosclerosis The study is ancillary to the Multi-Ethnic Study of Atherosclerosis MESA an NHLBI-supported epidemiological study of atherosclerosis in several ethnic groups
DESIGN NARRATIVE
A longitudinal assessment of the carotid intima media thickness IMT will be added to the scheduled follow-up visits in MESA subjects in order to study the relationship between carotid IMT and a measure of calcium burden in the coronary vessels In addition studies will be conducted on how these two non-invasive markers of atherosclerosis relate to cardiovascular disease risk factors and clinical eventsThe study will utilize the MESA cohort involving 6500 subjects who will have baseline and four follow-up examinations coronary artery calcification CAC and IMT are being obtained at baseline with CAC determinations also scheduled at follow-up IMT determinations will be added in conjunction with the CAC studies in the second and third exams and detailed analyses will be carried out on these two measures of atherosclerotic burden that may reflect different biologic processes
Cardiovascular disease remains the leading cause of death in the United States and one of the leading causes of morbidity New technology recently has allowed the non-invasive investigation of the extent of atherosclerosis in different vascular beds Unfortunately the clinical implications and significance of this new technology have not yet been fully examined nor has the interrelationship between these various measurements of clinical and sub-clinical atherosclerosis The study is ancillary to the Multi-Ethnic Study of Atherosclerosis MESA an NHLBI-supported epidemiological study of atherosclerosis in several ethnic groups
DESIGN NARRATIVE
A longitudinal assessment of the carotid intima media thickness IMT will be added to the scheduled follow-up visits in MESA subjects in order to study the relationship between carotid IMT and a measure of calcium burden in the coronary vessels In addition studies will be conducted on how these two non-invasive markers of atherosclerosis relate to cardiovascular disease risk factors and clinical eventsThe study will utilize the MESA cohort involving 6500 subjects who will have baseline and four follow-up examinations coronary artery calcification CAC and IMT are being obtained at baseline with CAC determinations also scheduled at follow-up IMT determinations will be added in conjunction with the CAC studies in the second and third exams and detailed analyses will be carried out on these two measures of atherosclerotic burden that may reflect different biologic processes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 5R01HL069003-05 | NIH | None | httpsreporternihgovquickSearch5R01HL069003-05 |