Ignite Creation Date:
2024-05-05 @ 10:47 PM
Last Modification Date:
2024-10-26 @ 10:24 AM
Study NCT ID:
NCT01188395
Status:
UNKNOWN
Last Update Posted:
2010-08-25
First Post:
2010-08-23
Brief Title:
Bipolar Disorder With Alcoholism in Han Chinese
Sponsor:
National Cheng-Kung University Hospital
Organization:
National Cheng-Kung University Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2010-08
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to explore relation between the comorbidity of different bipolar disorders with alcoholism and neuropsychiatric function and candidate genes The investigators plan to establish genetic validity for this subtype of alcoholism In addition by comparing this subtyped alcoholism to normal control the investigators plan to examine the genetic validity of such comorbidity The investigators plan to find specific clinical characteristic from neuropsychiatric aspects of such subtype for future early diagnosis prediction and prevention
Detailed Description:
From family twin and adoption studies supported a strong hereditary component in unsubtyped alcohol dependency Cloninger et al 1981 Reich et al 1999 Huang et al 2004 Dopamine serotonin related genes and ADH ALDH genes have been considered as candidate genes for alcohol dependency Goldman 1995 Reich et al 1999 Noble et al 2000 However both in simple or family-base association studies have generated controversy about the relationship between candidate genes and alcoholism Edenberg et al 1998 Reich et al 1999 Noble et al 2000 One of the possible explanations may be due to that those studies did not subtype alcohol dependency even though alcoholism is a complex phenotype with a heterogeneous etiology Huang et al 2004 Lu et al 2005a
Our previous research results had already categorized AD among Han Chinese in Taiwan into four subtypes pure alcoholism Pure ALC anxiety-depression alcoholism ANXDEP ALC antisocial alcoholism Antisocial ALC and mixed type alcoholism Mixed ALC Huang et al 2004 Lu et al 2005 Wang et al 2007 Except for Mixed ALC we have established fundamental genetic validity and confirmed several candidate genes including MAOAADHALDHDRD2
Mixed ALC is categorized by alcoholism comorbid with other psychiatric disorders including schizophrenia and bipolar disorder Among them all bipolar disorders most frequently comorbid with alcohol and substance dependence The high comorbidity between alcohol dependence among patients with bipolar disorder worsens the treatment effect and prognosis Bipolar disorders are divided into several categories including bipolar I disorder BP-I bipolar II disorder BP-II and cyclothymic disorder Previous literatures have documented that BP-I and BP-II might have different etiology phenomenology characteristics and neuropsychiatric functional impairments in the course of the illness APA 1994
The aim of this study is to explore relation between the comorbidity of different bipolar disorders with alcoholism and neuropsychiatric function and candidate genes We plan to establish genetic validity for this subtype of alcoholism In addition by comparing this subtyped alcoholism to normal control we plan to examine the genetic validity of such comorbidity We plan to find specific clinical characteristic from neuropsychiatric aspects of such subtype for future early diagnosis prediction and prevention
Our previous research results had already categorized AD among Han Chinese in Taiwan into four subtypes pure alcoholism Pure ALC anxiety-depression alcoholism ANXDEP ALC antisocial alcoholism Antisocial ALC and mixed type alcoholism Mixed ALC Huang et al 2004 Lu et al 2005 Wang et al 2007 Except for Mixed ALC we have established fundamental genetic validity and confirmed several candidate genes including MAOAADHALDHDRD2
Mixed ALC is categorized by alcoholism comorbid with other psychiatric disorders including schizophrenia and bipolar disorder Among them all bipolar disorders most frequently comorbid with alcohol and substance dependence The high comorbidity between alcohol dependence among patients with bipolar disorder worsens the treatment effect and prognosis Bipolar disorders are divided into several categories including bipolar I disorder BP-I bipolar II disorder BP-II and cyclothymic disorder Previous literatures have documented that BP-I and BP-II might have different etiology phenomenology characteristics and neuropsychiatric functional impairments in the course of the illness APA 1994
The aim of this study is to explore relation between the comorbidity of different bipolar disorders with alcoholism and neuropsychiatric function and candidate genes We plan to establish genetic validity for this subtype of alcoholism In addition by comparing this subtyped alcoholism to normal control we plan to examine the genetic validity of such comorbidity We plan to find specific clinical characteristic from neuropsychiatric aspects of such subtype for future early diagnosis prediction and prevention
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None