Ignite Creation Date:
2024-05-05 @ 10:46 PM
Last Modification Date:
2024-10-26 @ 10:23 AM
Study NCT ID:
NCT01182103
Status:
COMPLETED
Last Update Posted:
2014-08-15
First Post:
2010-08-11
Brief Title:
Epigenetic Regulation of BDNF in Major Depression
Sponsor:
Chang Gung Memorial Hospital
Organization:
Chang Gung Memorial Hospital
Study Overview
Official Title:
Epigenetic Regulation of Brain-Derived Neurotropic Factor BDNF in Patients With Major Depression
Status:
COMPLETED
Status Verified Date:
2014-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators will 1 detect the associations between brain-derived neurotrophic factor BDNF DNA methylation histone modification depressive symptoms suicidal behavior and antidepressant responses in major depressive disorder MDD patients 2 check the correlation between blood BDNF protein and RNA and BDNF rs6265 gene and 3 discuss the possible mechanisms of epigenetic regulation of BDNF in Taiwanese major depressive patients
Detailed Description:
Brain-derived neurotrophic factor BDNF had been chosen as a candidate gene for a development of major depressive disorder MDD BDNF had been reported to have an important role on neuronal plasticity axonal growth and connectivity and participating in the local response to various types of neuronal stressors BDNF also influences the differentiation of neurons
In the past studies the investigators had found that major depressive women had lower serum BDNF protein levels than healthy controls and their BDNF levels became significantly increased after antidepressant treatments In addition some authors had found that reduced expression of BDNF was noted in postmortem brain of completed suicide subjects Suicidal major depressive patients also had lower plasma BDNF levels than non-suicidal major depressive patients These findings suggested that BDNF might play an important role in the suicidal behavior
However in past studies the results did not fully explain why major depressive patients with same genotypes had different clinical expression including the severity of depression withwithout suicide and the treatment response Recently some papers found that there were relationships between epigenetic regulation including DNA methylation and histone modification and psychopathology of major depression Therefore we try to investigate the relationships between epigenetic regulation of BDNF and major depression
In the past studies the investigators had found that major depressive women had lower serum BDNF protein levels than healthy controls and their BDNF levels became significantly increased after antidepressant treatments In addition some authors had found that reduced expression of BDNF was noted in postmortem brain of completed suicide subjects Suicidal major depressive patients also had lower plasma BDNF levels than non-suicidal major depressive patients These findings suggested that BDNF might play an important role in the suicidal behavior
However in past studies the results did not fully explain why major depressive patients with same genotypes had different clinical expression including the severity of depression withwithout suicide and the treatment response Recently some papers found that there were relationships between epigenetic regulation including DNA methylation and histone modification and psychopathology of major depression Therefore we try to investigate the relationships between epigenetic regulation of BDNF and major depression
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None