Ignite Creation Date:
2024-05-05 @ 10:46 PM
Last Modification Date:
2024-10-26 @ 10:23 AM
Study NCT ID:
NCT01184248
Status:
COMPLETED
Last Update Posted:
2011-09-08
First Post:
2010-08-16
Brief Title:
The Effect of Sound Stimulation on Pure-tone Hearing Threshold
Sponsor:
Earlogic Korea Inc
Organization:
Earlogic Korea Inc
Study Overview
Official Title:
The Effect of Sound Stimulation on Pure-tone Hearing Threshold
Status:
COMPLETED
Status Verified Date:
2011-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate if sound stimulation could improve pure-tone hearing threshold
In the late 1990s researchers discovered that acoustic stimuli slow progressive sensorineural hearing loss and exposure to a moderately augmented acoustic environment can delay the loss of auditory function In addition prolonged exposure to an augmented acoustic environment could improve age-related auditory changes These ameliorative effects were shown in several types of mouse strains as long as the acoustic environment was provided prior to the occurrence of severe hearing loss
In addition to delaying progressive hearing loss acoustic stimuli could also protect hearing ability against damage by traumatic noise In particular a method called forward sound conditioning ie prior exposure to moderate levels of sound has been shown to reduce noise-induced hearing impairment in a number of mammalian species including humans
Interestingly recent report has suggested that low-level sound conditioning also reduces free radical-induced damage to hair cells increases antioxidant enzyme activity and reduces Cox-2 expression in cochlea and can enhance cochlear sensitivity Specifically increased cochlear sensitivity was observed when distortion product otoacoustic emissions DPOAEs and compound action potentials CAPs were measured
In addition to forward sound conditioning backward sound conditioning ie the use of acoustic stimuli after exposure to a traumatic noise has been shown to protect hearing ability against acoustic trauma and to prevent the cortical map reorganization induced by traumatic noise
Based on the results of animal studies the investigators conducted a human study in 2007 and observed that sound stimulation could improve hearing ability On average the pure-tone hearing threshold decreased by 891 dB after sound stimulation for 2 weeks In that study however the investigators observed only the hearing threshold changes by sound stimulation
To verify the previous ameliorative effect of sound stimulation the investigators included a control period in this study
In the late 1990s researchers discovered that acoustic stimuli slow progressive sensorineural hearing loss and exposure to a moderately augmented acoustic environment can delay the loss of auditory function In addition prolonged exposure to an augmented acoustic environment could improve age-related auditory changes These ameliorative effects were shown in several types of mouse strains as long as the acoustic environment was provided prior to the occurrence of severe hearing loss
In addition to delaying progressive hearing loss acoustic stimuli could also protect hearing ability against damage by traumatic noise In particular a method called forward sound conditioning ie prior exposure to moderate levels of sound has been shown to reduce noise-induced hearing impairment in a number of mammalian species including humans
Interestingly recent report has suggested that low-level sound conditioning also reduces free radical-induced damage to hair cells increases antioxidant enzyme activity and reduces Cox-2 expression in cochlea and can enhance cochlear sensitivity Specifically increased cochlear sensitivity was observed when distortion product otoacoustic emissions DPOAEs and compound action potentials CAPs were measured
In addition to forward sound conditioning backward sound conditioning ie the use of acoustic stimuli after exposure to a traumatic noise has been shown to protect hearing ability against acoustic trauma and to prevent the cortical map reorganization induced by traumatic noise
Based on the results of animal studies the investigators conducted a human study in 2007 and observed that sound stimulation could improve hearing ability On average the pure-tone hearing threshold decreased by 891 dB after sound stimulation for 2 weeks In that study however the investigators observed only the hearing threshold changes by sound stimulation
To verify the previous ameliorative effect of sound stimulation the investigators included a control period in this study
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None