Ignite Creation Date:
2024-05-05 @ 10:44 PM
Last Modification Date:
2024-10-26 @ 10:23 AM
Study NCT ID:
NCT01178580
Status:
COMPLETED
Last Update Posted:
2011-09-07
First Post:
2010-08-08
Brief Title:
Procoagulant Activity in Patients With Community Acquired Pneumonia Pleural Effusion and Empyema
Sponsor:
Meir Medical Center
Organization:
Meir Medical Center
Study Overview
Official Title:
Procoagulant Activity in Patients With Community Acquired Pneumonia Pleural Effusion and Empyema
Status:
COMPLETED
Status Verified Date:
2011-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Community acquired pneumonia CAP is still one of the most important causes of morbidity in adults 1 In severe cases parapneumonic effusions or empyema may develop In these patients a transitional fibrin neomatrix constitutes part of the acute inflammatory response as seen in sepsis
The aim is to study the fibrinolytic activity in patients with CAP alone versus CAP with parapneumonic effusions with and without empyema
The aim is to study the fibrinolytic activity in patients with CAP alone versus CAP with parapneumonic effusions with and without empyema
Detailed Description:
Community acquired pneumonia CAP is still one of the most important causes of morbidity in adults 1 In severe cases parapneumonic effusions or empyema may develop In these patients a transitional fibrin neomatrix constitutes part of the acute inflammatory response as seen in sepsis 2 The increased vascular permeability mediated by several cytokines such as IL-1 IL-6 IL-8 tumor necrosis factor TNF and platelet activator factor allows migration of inflammatory cells an increased fluid accumulation and bacterial invasion into pleural space 3 At this stage activation of the coagulation cascade leads to procoagulant activity and decreased fibrinolysis with deposition of fibrin in the pleural space The activation of the fibrinolytic system produce the D-dimer and follow by increased other procoagulant markers like thrombin anti thrombin fragment 12 4-5 Several studies showed that the plasma D-dimer levels were increased even in community-acquired pneumonia patients Moreover others reported that Serum levels of AT-III D-D and CRP at admission appear to be useful biomarkers for assessing the severity of CAP However no data exists about the fibrinolytic profile in patients with CAP alone in compare to CAP with parapneumonic effusion with and without empyema
Aim
To study the fibrinolytic activity in patients with CAP alone versus CAP with parapneumonic effusions with and without empyema
Aim
To study the fibrinolytic activity in patients with CAP alone versus CAP with parapneumonic effusions with and without empyema
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None