Ignite Creation Date:
2024-05-05 @ 10:43 PM
Last Modification Date:
2024-10-26 @ 10:23 AM
Study NCT ID:
NCT01176591
Status:
COMPLETED
Last Update Posted:
2020-07-15
First Post:
2010-08-04
Brief Title:
HBPL Study of the Impact of the NK1 Antagonist Aprepitant
Sponsor:
University of Pennsylvania
Organization:
University of Pennsylvania
Study Overview
Official Title:
Human Behavioral Pharmacology Laboratory HBPL Study of the Impact of the NK1 Antagonist Aprepitant Emend on Stress-Induced Cocaine and Alcohol Craving
Status:
COMPLETED
Status Verified Date:
2020-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The proposed research will focus on investigating the determinants and consequences of CAD via measurement of physiological behavioral and subjective effects of physiologic and psychologic stress cues in CAD volunteers in the laboratory and through examination of the effects of the effects of Aprepitant an NK1 antagonist on the above effects This study will examine the effects of the above stress cues on cocaine and alcohol craving under acute Aprepitant dosing and under placebo conditions The study is a within-subjects crossover design using 24 subjects
Detailed Description:
Non treatment seeking subjects with DSM IV cocaine and alcohol dependence were included Subjects received double-blind acute dosing of 80 mg of aprepitant Emend at session start or matched placebo During each session subjects were exposed to one of two types of stressors one stressor per session presented in counterbalanced order across participants The Physiologic stress was the cold-pressor task Subjects immersed their hand in cold water for up to 3 minutes The psychological stress was the Trier Social Stress Test it was completed in 25 minutes 5 min audio taped instructions 10 min to mentally prepare for their performance tasks 5 min to complete a public speaking task and 5 min to complete a mental arithmetic task Outcome measures included Alcohol Craving measured by visual analog scale cocaine craving measured by visual analog scale and The Multiple Choice Procedure Each assessment was done during study screening and then at multiple times during each study session
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| K01DA025073 | NIH | None | httpsreporternihgovquickSearchK01DA025073 |