Ignite Creation Date:
2024-05-05 @ 10:41 PM
Last Modification Date:
2024-10-26 @ 10:23 AM
Study NCT ID:
NCT01169831
Status:
COMPLETED
Last Update Posted:
2023-04-13
First Post:
2010-07-23
Brief Title:
Regulation of Endothelial Progenitor Cells by Short-Term Exercise
Sponsor:
Baltimore VA Medical Center
Organization:
Baltimore VA Medical Center
Study Overview
Official Title:
Regulation of Endothelial Progenitor Cells by Short-Term Exercise
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EPC-Ex
Brief Summary:
Endothelial Progenitor Cells EPCs are circulating cells released from bone marrow which are important for maintaining cardiovascular health The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers Studies have shown reduced EPC number and function in old vs young individuals and endurance exercise training increases EPC number and function in young adults Oxidative stress adversely affects endothelial cells and preliminary evidence indicates that oxidative stress negatively affects EPC function Conversely regular exercise reduces markers of oxidative stress and may enhance EPC function in older adults The investigators hypothesize that older endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC function and that altering the physical activity levels of both groups will move them to intermediate points between these two extremes The investigators also propose that the investigators can mimic the effect of exercise training on EPC function in cell culture by altering intracellular levels of a key enzyme and a signaling molecule which the investigators have shown to regulate EPC function with respect to exercise training in young individuals
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None