Ignite Creation Date:
2025-12-25 @ 12:36 AM
Ignite Modification Date:
2025-12-26 @ 1:26 PM
Study NCT ID:
NCT07146867
Status:
COMPLETED
Last Update Posted:
2025-08-28
First Post:
2025-08-21
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Effects of One HIIT Session on Adiponectin Isoforms
Sponsor:
Universidad San Sebastián
Organization:
Study Overview
Official Title:
Metabolic Responses to a Single Session of High-intensity Interval Training in Insufficiently Active Young Adults. Effects on Adiponectin Isoforms
Status:
COMPLETED
Status Verified Date:
2025-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational quasi-experimental study is to evaluate whether a single session of high-intensity interval training (HIIT) can acutely modulate metabolic markers, particularly adiponectin isoforms, in insufficiently active young adults (men and women, 18-29 years, free of cardiometabolic disease).
The main questions it aims to answer are:
Does a single HIIT session increase circulating medium- and high-molecular-weight adiponectin?
Does HIIT acutely alter lipid and glucose metabolism markers such as non-HDL cholesterol, insulin, and lactate?
Participants completed the following tasks:
Underwent baseline assessments (anthropometry, body composition, and resting cardiovascular parameters).
Performed one HIIT session consisting of six 3-minute intervals at 80% heart rate reserve, each followed by 3 minutes of active recovery.
Provided blood samples before and immediately after exercise to analyze adiponectin isoforms (LMW, MMW, HMW) via Western blot and to measure glucose, insulin, lipid profile, liver enzymes, and lactate.
Summary of findings:
A single HIIT session significantly increased medium-molecular-weight adiponectin (\~19%), decreased the HMW/MMW ratio, and elevated lactate and non-HDL cholesterol. No significant changes were observed in LMW or HMW adiponectin. These results suggest that MMW adiponectin is an early, sensitive marker of acute exercise response in sedentary young adults, though further research is needed to confirm long-term implications
The main questions it aims to answer are:
Does a single HIIT session increase circulating medium- and high-molecular-weight adiponectin?
Does HIIT acutely alter lipid and glucose metabolism markers such as non-HDL cholesterol, insulin, and lactate?
Participants completed the following tasks:
Underwent baseline assessments (anthropometry, body composition, and resting cardiovascular parameters).
Performed one HIIT session consisting of six 3-minute intervals at 80% heart rate reserve, each followed by 3 minutes of active recovery.
Provided blood samples before and immediately after exercise to analyze adiponectin isoforms (LMW, MMW, HMW) via Western blot and to measure glucose, insulin, lipid profile, liver enzymes, and lactate.
Summary of findings:
A single HIIT session significantly increased medium-molecular-weight adiponectin (\~19%), decreased the HMW/MMW ratio, and elevated lactate and non-HDL cholesterol. No significant changes were observed in LMW or HMW adiponectin. These results suggest that MMW adiponectin is an early, sensitive marker of acute exercise response in sedentary young adults, though further research is needed to confirm long-term implications
Detailed Description:
None
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: