Ignite Creation Date:
2024-05-05 @ 10:40 PM
Last Modification Date:
2024-10-26 @ 10:22 AM
Study NCT ID:
NCT01163500
Status:
COMPLETED
Last Update Posted:
2013-10-14
First Post:
2010-07-13
Brief Title:
Coenzyme Q10 in Relation of the Lipid Peroxidation Antioxidant Enzyme Activities in Coronary Artery Disease Patients
Sponsor:
Taichung Veterans General Hospital
Organization:
Taichung Veterans General Hospital
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2013-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Coenzyme Q10 Ubiquinone is recognized as an endogenous fat-soluble antioxidant in the mitochondrial membrane and considered as a preventive factor for coronary artery disease CAD However the relationships between coenzyme Q10 and the prevention of the risk of CAD are still inconsistent The purposes of this study are to investigate the relation of coenzyme Q10 concentration with the blood lipid levels plasma homocysteine the markers of lipid peroxidation TBARS ox-LDLantioxidant enzymes activities catalase glutathione peroxidase superoxide dismutaseand to examine the association with the risk of CADThe CAD patients is identified by cardiac catheterization as having at least 50 stenosis of one major coronary artery n 100 The second year is a double-blind placebo-controlled intervention study CAD subjects n 60 are randomly assign to one of the three groups coenzyme Q10 supplements 60 mgd 150 mgd and placebo groups n 20group Intervention is going to administration for three months The third year is a case-control study The control group n 100 is comprised of healthy individuals with normal blood biochemical values and match by age and gender with the first year CAD subjects case group Fasting blood samples will be obtain to determine the concentration of coenzyme Q10 homocysteine the markers of lipid peroxidationantioxidant enzymes activities The differences between case and control groups will be compared by using Students t-test Conditional logistical regression model will be performed to calculate the odds ratio for CAD based on coenzyme Q10 level Hopefully the results of this study could provide the information to what has been know in CAD subjects We expect coenzyme Q10 could be a preventive supplement to reduce the risk of CAD
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None