Ignite Creation Date:
2024-05-05 @ 10:39 PM
Last Modification Date:
2024-10-26 @ 10:22 AM
Study NCT ID:
NCT01155791
Status:
TERMINATED
Last Update Posted:
2017-03-15
First Post:
2010-06-30
Brief Title:
Phase I Sodium Selenite in Combination With Docetaxel in Castration-resistant Prostate Cancer
Sponsor:
Sandy Srinivas
Organization:
Stanford University
Study Overview
Official Title:
A Phase I Study Evaluating the Efficacy and Safety of Sodium Selenite in Combination With Docetaxel in Castration-resistant Prostate Cancer
Status:
TERMINATED
Status Verified Date:
2017-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Selenium in the form of inorganic Sodium Selenite may be useful for treating existing prostate cancer This idea is based on data from our laboratory showing that 1 prostate cancer cells are more sensitive to Selenium Sodium Selenite-induced apoptosis than normal prostate epithelial cells 2 Selenite induces significant growth inhibition of well established prostate cancer tumors in mice at doses that have no detectable toxicity and 3 Selenite disrupts AR signaling and that the inhibition of AR expression and activity by Selenite occurs via a redox mechanism involving GSH superoxide and Sp1 Altogether these findings suggest that Selenium may be useful in a variety of potential indications in the natural history of prostate cancer including both hormone sensitive and castrate resistant prostate cancer as a single agent or in combination with radiation chemotherapy or conventional hormone therapy Selenite is a potential novel inhibitor of AR expression and function in prostate cancer
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| SU-05122010-6002 | OTHER | None | None |
| 17356 | OTHER | Stanford IRB | None |