Ignite Creation Date:
2024-05-05 @ 11:29 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00055003
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2003-02-15
Brief Title:
Effect of Hydrocortisone on the Brain
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Effects of Hydrocortisone Infusion on Processing of Facially Expressed Emotion During Functional Magnetic Resonance Imaging
Status:
COMPLETED
Status Verified Date:
2010-11-18
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to use brain imaging technology to examine the effect of the hormone hydrocortisone on the brains response to various facial expressions
Glucocorticoids can influence emotional behavior and cognition when given long-term the hormones may lead to mania or depression One way glucocorticoids may influence emotional behavior is by affecting the activity of certain parts of the brain that participate in emotional processing Brain imaging studies indicate that the amygdala ventral medial prefrontal and other prefrontal cortical areas of the brain are activated during tasks that require processing of emotional stimuli These brain structures contain dense concentrations of glucocorticoid receptors This study will use functional magnetic resonance imaging fMRI to study the brain activity of participants as they view faces that express different emotions Participants will perform this task under a dose of either the glucocorticoid hydrocortisone or placebo an inactive solution
Participants in this study will be screened with a medical history physical examination blood tests and an interview about their mood degree of nervousness and behavior On Visit 1 participants will undergo screening and neuropsychological testing For 3 days prior to Visit 2 participants will collect their saliva During Visit 2 participants will undergo MRI scans of the brain after infusion with either a high or low dose of hydrocortisone or placebo Participants will also undergo functional MRI fMRI Blood samples will be collected every 15 minutes during the scan Following the MRI participants will take attention and memory tests
Glucocorticoids can influence emotional behavior and cognition when given long-term the hormones may lead to mania or depression One way glucocorticoids may influence emotional behavior is by affecting the activity of certain parts of the brain that participate in emotional processing Brain imaging studies indicate that the amygdala ventral medial prefrontal and other prefrontal cortical areas of the brain are activated during tasks that require processing of emotional stimuli These brain structures contain dense concentrations of glucocorticoid receptors This study will use functional magnetic resonance imaging fMRI to study the brain activity of participants as they view faces that express different emotions Participants will perform this task under a dose of either the glucocorticoid hydrocortisone or placebo an inactive solution
Participants in this study will be screened with a medical history physical examination blood tests and an interview about their mood degree of nervousness and behavior On Visit 1 participants will undergo screening and neuropsychological testing For 3 days prior to Visit 2 participants will collect their saliva During Visit 2 participants will undergo MRI scans of the brain after infusion with either a high or low dose of hydrocortisone or placebo Participants will also undergo functional MRI fMRI Blood samples will be collected every 15 minutes during the scan Following the MRI participants will take attention and memory tests
Detailed Description:
Glucocorticoids influence performance on declarative memory tasks and tasks of memory for emotional information The cognitive effects of exogenous glucocorticoids depend on dose the time period between administration and testing and the time of testing within the diurnal pattern of cortisol secretion Additionally glucocorticoid administration can influence mood and with chronic administration glucocorticoids may lead to development of mania or depression
A potential mechanism by which glucocorticoids may influence emotional behavior is via their effects on the neurophysiological activity of the amygdala and prefrontal cortical structures known to participate in emotional processing Human imaging studies indicate that amygdala ventral medial prefrontal and other prefrontal cortical areas are activated during tasks requiring processing of affective stimuli These data converge with lesion analysis and electrophysiological studies performed in humans or experimental animals to indicate that these structures participate in brain circuits that process emotional information These brain structures contain dense concentrations of glucocorticoid and mineralocorticoid receptor mRNA glucocorticoid receptors and mineralocorticoid receptors Increased glucocorticoids appear to potentiate activation of the amygdala and affect processing of emotionally laden stimuli based on both experimental animal studies and correlational human studies
The present study investigates the influence of glucocorticoids on the hemodynamic response that occurs while processing emotionally-valenced visual stimuli known to activate the amygdala and anatomically-related areas of the prefrontal cortex PFC in healthy humans Functional magnetic resonance images will be acquired during the performance of tasks that involve viewing emotionally expressive faces both before and following either hydrocortisone synthetic cortisol 015 mgkg or 045 mgkg bolus or placebo administration The change in the BOLD signal in structures of interest will be compared across high dose cortisol low dose cortisol and placebo conditions In addition the effects of hydrocortisone on relative blood flow in the amygdala and PFC will be assessed using an arterial spin labeling ASL technique to measure perfusion The findings of this study will guide future research into the effects of glucocorticoids on emotional perception in subjects with mood disorders
A potential mechanism by which glucocorticoids may influence emotional behavior is via their effects on the neurophysiological activity of the amygdala and prefrontal cortical structures known to participate in emotional processing Human imaging studies indicate that amygdala ventral medial prefrontal and other prefrontal cortical areas are activated during tasks requiring processing of affective stimuli These data converge with lesion analysis and electrophysiological studies performed in humans or experimental animals to indicate that these structures participate in brain circuits that process emotional information These brain structures contain dense concentrations of glucocorticoid and mineralocorticoid receptor mRNA glucocorticoid receptors and mineralocorticoid receptors Increased glucocorticoids appear to potentiate activation of the amygdala and affect processing of emotionally laden stimuli based on both experimental animal studies and correlational human studies
The present study investigates the influence of glucocorticoids on the hemodynamic response that occurs while processing emotionally-valenced visual stimuli known to activate the amygdala and anatomically-related areas of the prefrontal cortex PFC in healthy humans Functional magnetic resonance images will be acquired during the performance of tasks that involve viewing emotionally expressive faces both before and following either hydrocortisone synthetic cortisol 015 mgkg or 045 mgkg bolus or placebo administration The change in the BOLD signal in structures of interest will be compared across high dose cortisol low dose cortisol and placebo conditions In addition the effects of hydrocortisone on relative blood flow in the amygdala and PFC will be assessed using an arterial spin labeling ASL technique to measure perfusion The findings of this study will guide future research into the effects of glucocorticoids on emotional perception in subjects with mood disorders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-M-0102 | None | None | None |