Viewing Study NCT01151826



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Last Modification Date: 2024-10-26 @ 10:21 AM
Study NCT ID: NCT01151826
Status: UNKNOWN
Last Update Posted: 2011-03-02
First Post: 2010-06-25

Brief Title: Quantifying Physical and Biochemical Factors That Contribute to Primary Graft Dysfunction After Lung Transplantation
Sponsor: University Hospital Strasbourg France
Organization: University Hospital Strasbourg France

Study Overview

Official Title: Measurement of Physical and Biochemical Markers of Reperfusion Edema During Primary Graft Dysfunction Following Lung Transplantation Assessment of Their Diagnosis and Prognosis Values
Status: UNKNOWN
Status Verified Date: 2011-03
Last Known Status: RECRUITING
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: Primary graft dysfunction PGD or lung reperfusion edema complicates 10 to 20 of lung transplantations and leads to severe early and late postoperative complications Its pathophysiology remains unclear but may involve graft ischemia-reperfusion increased vascular permeability pneumocyte dysfunction and finally alveolar flooding that impair gas exchange and blood oxygenationIts substrate namely extravascular lung water EVLW can now be clinically measured with minimally invasive Intensive Care Unit monitors PiCCO2 Pulsion Medical Systems that also provides a physical estimate of pulmonary vascular permeability PVPI Similarly biochemical correlates of vascular permeability ICAM-1 and pneumocyte dysfunction RAGE can now be measured in plasma samples Our study aims at quantifying physical and biochemical markers of PGD and assess their diagnosis and prognosis values
Detailed Description: None

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: None
Is a FDA Regulated Device?: None
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None