Ignite Creation Date:
2024-05-05 @ 10:37 PM
Last Modification Date:
2024-10-26 @ 10:21 AM
Study NCT ID:
NCT01141673
Status:
UNKNOWN
Last Update Posted:
2011-04-26
First Post:
2010-06-08
Brief Title:
Development of a Diagnostic Kit for FLT3-ITD in Acute Myeloid Leukemia
Sponsor:
Taipei Medical University WanFang Hospital
Organization:
Taipei Medical University WanFang Hospital
Study Overview
Official Title:
Development of a Diagnostic Kit for FLT3-ITD in Acute Myeloid Leukemia
Status:
UNKNOWN
Status Verified Date:
2011-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
FLT3 overexpression in acute myeloid leukemia AML is often caused by mutations in this gene These mutations cause constitutive phosphorylation of FLT3 proteins leading to increased proliferation and survival decreased apoptosis and resistance to chemotherapeutic agents in AML cells There are two major types of FLT3 mutations- internal tandem duplication ITD and point mutation at 835th amino residue AMLs with FLT3 mutations have worse prognosis and are often resistant to conventional chemotherapy Several small molecule compounds targeting FLT3 have been in the market or in clinical trials Therefore identification of these mutations at the time of diagnosis will provide a better prognostic prediction might guide the treatment selection and follow-up strategies In this study the investigators will develop a sensitive molecular assay to detect FLT3 mutations for future clinical application The investigators will collect 100 AML samples with at least 20 samples with known FLT3 mutations The investigators will compare this assay with commonly used methods and standardize the procedure to meet the requirement of clinical pathology laboratory with reasonable cost
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None