Ignite Creation Date:
2024-05-05 @ 10:35 PM
Last Modification Date:
2024-10-26 @ 10:20 AM
Study NCT ID:
NCT01137942
Status:
UNKNOWN
Last Update Posted:
2010-07-12
First Post:
2010-06-02
Brief Title:
The Role of Cathepsin X in Infection With the Helicobacter Pylori
Sponsor:
University Medical Centre Ljubljana
Organization:
University Medical Centre Ljubljana
Study Overview
Official Title:
Helicobacter Pylori and Gastric Cancer - the Role of Cytokine Polymorphism Cytokine Expression and Expression of TLR on Persistence of Helicobacter Pylori Infection and Development of Gastric Cancer
Status:
UNKNOWN
Status Verified Date:
2010-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The immune response to Helicobacter pylori Hp importantly determines the pathogenesis of infection as well as the success of antibiotic eradication of the bacteria The investigators want to demonstrate the importance of cathepsin X CTSX a cysteine protease for the Hp eradication success The diversity of the innate immune response to H pylori antigens leading to either successful eradication of the infection or maintenance of chronic inflammation is connected to CTSX The aim of this study is to determine whether H pylori suppresses the CTSX expression and cytokine secretion in macrophage cell line THP-1 in the individuals that are not capable of eradicating the infection opposite to H pylori in patients with successful H pylori eradication The investigators also investigate the possibility whether strain-dependent differences in H pylori lipopolysaccharide LPS influence the CTSX expression and cytokine secretion
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1000-05-310123 | OTHER_GRANT | Slovenian Research Agency ARRS | None |