Ignite Creation Date:
2024-05-05 @ 11:29 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00055224
Status:
COMPLETED
Last Update Posted:
2024-01-09
First Post:
2003-02-21
Brief Title:
Expectation of Unpleasant Events in Anxiety Disorders
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Predictability and Aversive Expectancies in Anxiety and Depressive Disorders
Status:
COMPLETED
Status Verified Date:
2022-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Fear and anxiety are normal responses to a threat However anxiety is considered abnormal when the response to the threat is excessive or inappropriate This study will examine changes in the body and brain that occur during unpleasant learning experiences in healthy volunteers with high moderate and low levels of anxiety
A high degree of generalized anxiety is a component of many anxiety disorders and is regarded as a marker of vulnerability for these disorders People with anxiety disorders and individuals with high degrees of anxiety have inappropriate expectations of unpleasant events This study will investigate the development of expecting unpleasant events in healthy volunteers with varying degrees of anxiety using aversive conditioning models A later phase of the study will enroll participants with anxiety disorders and compare their responses to those of healthy volunteers
Patients who meet criteria for an anxiety disorder and healthy volunteers who have no history of psychiatric or major medical illness will be enrolled in this study Volunteers will come to the NIH Clinical Center three times for outpatient testing
A high degree of generalized anxiety is a component of many anxiety disorders and is regarded as a marker of vulnerability for these disorders People with anxiety disorders and individuals with high degrees of anxiety have inappropriate expectations of unpleasant events This study will investigate the development of expecting unpleasant events in healthy volunteers with varying degrees of anxiety using aversive conditioning models A later phase of the study will enroll participants with anxiety disorders and compare their responses to those of healthy volunteers
Patients who meet criteria for an anxiety disorder and healthy volunteers who have no history of psychiatric or major medical illness will be enrolled in this study Volunteers will come to the NIH Clinical Center three times for outpatient testing
Detailed Description:
High-generalized anxiety is a concomitant of many anxiety disorders and is often regarded as a vulnerability marker for these disorders One characteristic of patients with anxiety disorders and high trait-anxious individuals is inappropriate expectancies of aversive events The overall aim of the present protocol is to investigate mechanisms that may promote the development of these aversive expectancies using expectancy-based associative-learning models
During aversive conditioning in which a phasic explicit-cue eg a light is repeatedly associated with an aversive unconditioned-stimulus eg a shock the organism develops fear to the explicit cue as well as to the environmental context in which the experiment took place We have obtained preliminary evidence suggesting that contextual fear represents aspects of aversive states that are central to anxiety disorders In this protocol we seek further evidence for the relevance of contextual fear to mood anxiety disorders
One important determinant of contextual fear in both humans and animals is predictability contextual fear increases when aversive events eg electric shock are unpredictable as opposed to when they are predictable The present protocol will examine the role of predictability of aversive states and of conditioning on threat appraisal in individuals with mood and anxiety disorders
A second aim is to examine the interaction between experimentally-induced anxiety and cognitive processes more specifically working memory in mood and anxiety disorders
During aversive conditioning in which a phasic explicit-cue eg a light is repeatedly associated with an aversive unconditioned-stimulus eg a shock the organism develops fear to the explicit cue as well as to the environmental context in which the experiment took place We have obtained preliminary evidence suggesting that contextual fear represents aspects of aversive states that are central to anxiety disorders In this protocol we seek further evidence for the relevance of contextual fear to mood anxiety disorders
One important determinant of contextual fear in both humans and animals is predictability contextual fear increases when aversive events eg electric shock are unpredictable as opposed to when they are predictable The present protocol will examine the role of predictability of aversive states and of conditioning on threat appraisal in individuals with mood and anxiety disorders
A second aim is to examine the interaction between experimentally-induced anxiety and cognitive processes more specifically working memory in mood and anxiety disorders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-M-0093 | None | None | None |