Ignite Creation Date:
2024-05-05 @ 10:31 PM
Last Modification Date:
2024-10-26 @ 10:20 AM
Study NCT ID:
NCT01128127
Status:
WITHDRAWN
Last Update Posted:
2012-09-14
First Post:
2010-05-20
Brief Title:
Strategies for Improving Proton Pump Inhibitors PPIs Prescription Associated to Non-steroidal Anti-inflammatory Drugs NSAIDs
Sponsor:
Servicio Canario de Salud
Organization:
Servicio Canario de Salud
Study Overview
Official Title:
Strategies for Improving Proton Pump Inhibitors PPIs Prescription for Gastropathy Prevention Due to Non-steroidal Anti-inflammatory Drugs NSAIDs in Primary Health Care
Status:
WITHDRAWN
Status Verified Date:
2012-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background
Despite the low prevalence of serious complications associated with non-steroidal anti-inflammatory drugs NSAIDs use there is a widespread use of gastroprotective proton pump inhibitors PPIs in order to prevent adverse effects Inappropriate prescribing of PPIs includes overprescribing for inappropriate indications and the misuse of first choice in their class in terms of efficacy safety and cost A series of recommendations based on the best available scientific evidence has been established to justify prophylaxis with PPIs associated to NSAIDs Therefore there is the need to encourage the incorporation of this knowledge to guide decisions of physicians with the objective of improving patient health and sustainability of the Public Health Service Although since long ago there is a great concern regarding rational use of drugs the available evidence for the most appropriate strategies to improve prescribing is scarce Passive dissemination of research findings are generally ineffective and at best result in small changes in practice Multifaceted intervention targeting different barriers to change are more likely to be effective than single intervention
Objectives
The objective of this study is to evaluate the effectiveness of two educational multifaceted strategies aimed at improving PPIs prescription associated to NSAIDs use in primary care We will also compare the cost-effectiveness of such strategies
Hypothesis
It is hypothesized that a quality improvement intervention directed to primary care physicians will decrease inappropriate PPIs prescriptions associated to NSAIDs prescription
Methodology
A three-arm prospective quasi-randomized controlled trial will test the effectiveness of two strategies for improving PPI prescription associated to NSAID in primary care context Three of the Canary Islands will be selected and randomized to either a experimental multifaceted intervention group educationaudit-feedbackCCDSS group a experimental multifaceted intervention audit-feedbackCCDSS group or a control group usual intervention From each of these islands 6-8 primary care centers will be randomly selected to received the intervention practices All family physicians working at each randomly selected primary care center were mandatorily included Primary outcome measure is reduction of inappropriate PPI prescription The efficacy of the intervention will be examined within a 3 6 and a 12 month follow up
Despite the low prevalence of serious complications associated with non-steroidal anti-inflammatory drugs NSAIDs use there is a widespread use of gastroprotective proton pump inhibitors PPIs in order to prevent adverse effects Inappropriate prescribing of PPIs includes overprescribing for inappropriate indications and the misuse of first choice in their class in terms of efficacy safety and cost A series of recommendations based on the best available scientific evidence has been established to justify prophylaxis with PPIs associated to NSAIDs Therefore there is the need to encourage the incorporation of this knowledge to guide decisions of physicians with the objective of improving patient health and sustainability of the Public Health Service Although since long ago there is a great concern regarding rational use of drugs the available evidence for the most appropriate strategies to improve prescribing is scarce Passive dissemination of research findings are generally ineffective and at best result in small changes in practice Multifaceted intervention targeting different barriers to change are more likely to be effective than single intervention
Objectives
The objective of this study is to evaluate the effectiveness of two educational multifaceted strategies aimed at improving PPIs prescription associated to NSAIDs use in primary care We will also compare the cost-effectiveness of such strategies
Hypothesis
It is hypothesized that a quality improvement intervention directed to primary care physicians will decrease inappropriate PPIs prescriptions associated to NSAIDs prescription
Methodology
A three-arm prospective quasi-randomized controlled trial will test the effectiveness of two strategies for improving PPI prescription associated to NSAID in primary care context Three of the Canary Islands will be selected and randomized to either a experimental multifaceted intervention group educationaudit-feedbackCCDSS group a experimental multifaceted intervention audit-feedbackCCDSS group or a control group usual intervention From each of these islands 6-8 primary care centers will be randomly selected to received the intervention practices All family physicians working at each randomly selected primary care center were mandatorily included Primary outcome measure is reduction of inappropriate PPI prescription The efficacy of the intervention will be examined within a 3 6 and a 12 month follow up
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None