Viewing Study NCT01127399



Ignite Creation Date: 2024-05-05 @ 10:30 PM
Last Modification Date: 2024-10-26 @ 10:20 AM
Study NCT ID: NCT01127399
Status: TERMINATED
Last Update Posted: 2018-02-05
First Post: 2010-05-19

Brief Title: Bariatric and Obstructive Lung Disease Study II
Sponsor: Johns Hopkins University
Organization: Johns Hopkins University

Study Overview

Official Title: Effects of Obesity on Airway Caliber and Airway Smooth Muscle Tone
Status: TERMINATED
Status Verified Date: 2018-01
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Funding revoked
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: BOLD II
Brief Summary: The prevalence of obesity and asthma has significantly increased over the past two decades The purpose of this study is to try and understand the mechanism by which obesity leads to airway hyperresponsiveness AHR one of the defining features of asthma This research is being done to determine how weight or body size affects airway size and airway smooth muscle ASM tone and function The goal of the study will be to look at if and how weight might affect lung functioning

The investigators hypothesize that low lung volumes in obesity lead to AHR by reducing airway caliber causing increased ASM tone with impairment in deep inspiration DI response similar to what is seen in asthma
Detailed Description: None

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: None
Is a FDA Regulated Device?: None
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None
Secondary IDs
Secondary ID Type Domain Link
K23HL097081 NIH None httpsreporternihgovquickSearchK23HL097081