Ignite Creation Date:
2024-05-05 @ 10:30 PM
Last Modification Date:
2024-10-26 @ 10:20 AM
Study NCT ID:
NCT01128400
Status:
COMPLETED
Last Update Posted:
2018-07-17
First Post:
2010-05-20
Brief Title:
Fat Perception in Humans 09-0873
Sponsor:
Washington University School of Medicine
Organization:
Washington University School of Medicine
Study Overview
Official Title:
Inhibition of Lipolysis in Oral Cavity and Fat Perception in Humans
Status:
COMPLETED
Status Verified Date:
2018-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
OT
Brief Summary:
There are many substances naturally present in the mouth that may help us taste fat in food Two of these substances lipases and CD36 will be examined in this study
The presence of fat in food increases food tastiness therefore people often over-eat high-fat foods and gain weight The purpose of this study is to determine if blocking lipases and some genetic variations in the CD36 gene will make fatty food less tasty so that people eat less Our hypothesis is that Orlistat and a particular gene will increase ones ability to detect fat
The presence of fat in food increases food tastiness therefore people often over-eat high-fat foods and gain weight The purpose of this study is to determine if blocking lipases and some genetic variations in the CD36 gene will make fatty food less tasty so that people eat less Our hypothesis is that Orlistat and a particular gene will increase ones ability to detect fat
Detailed Description:
1 Determine the effect of lipolysis inhibition in oral cavity on orosensory detection of fat in humans
Hypothesis Orally applied Orlistat will increase detection thresholds of TAGs but not FFA in humans
To test this hypothesis we will measure triolein a TAG and oleic acid a FFA taste detection thresholds with a three-alternative forced-choice 3-AFC ascending concentration method under two conditions Orlistat day vs Control day To control for olfactory input subjects will be assessed wearing noseclips
2 Determine the effect of CD36 variants on fat taste perception in humans Hypothesis SNPs that associate with reduced CD36 expression will be associated with higher FFA and TAG detection thresholds
To test this hypothesis we will measure triolein and oleic acid taste detection thresholds in subjects who carry of the common CD36 e-SNP rs1761667 ie a SNP that significantly reduces CD36 level and has a minor allele frequency of 38-48 We expect subjects who are at least heterozygous for the expression reducing allele to have higher triolein and oleic acid taste detection thresholds compared to non-carrier subjects
Hypothesis Orally applied Orlistat will increase detection thresholds of TAGs but not FFA in humans
To test this hypothesis we will measure triolein a TAG and oleic acid a FFA taste detection thresholds with a three-alternative forced-choice 3-AFC ascending concentration method under two conditions Orlistat day vs Control day To control for olfactory input subjects will be assessed wearing noseclips
2 Determine the effect of CD36 variants on fat taste perception in humans Hypothesis SNPs that associate with reduced CD36 expression will be associated with higher FFA and TAG detection thresholds
To test this hypothesis we will measure triolein and oleic acid taste detection thresholds in subjects who carry of the common CD36 e-SNP rs1761667 ie a SNP that significantly reduces CD36 level and has a minor allele frequency of 38-48 We expect subjects who are at least heterozygous for the expression reducing allele to have higher triolein and oleic acid taste detection thresholds compared to non-carrier subjects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None