Ignite Creation Date:
2024-05-05 @ 11:29 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00059436
Status:
COMPLETED
Last Update Posted:
2016-09-26
First Post:
2003-04-25
Brief Title:
Mental Effort and Muscle Strength
Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD
Organization:
Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD
Study Overview
Official Title:
Mental-effort Effect on Large Muscle Strengthening
Status:
COMPLETED
Status Verified Date:
2011-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine the effect of mental effort on improving muscle strength
Detailed Description:
Training that involves heavy loads or resistance strengthens muscles Recent data suggest that substantial voluntary strength gains can be achieved with training involving low resistance and strong mental effort In contrast individuals who train with the same low intensity contractions but with low mental effort show no improvement in strength
This study will evaluate the relationship between mental effort muscle strength improvements by comparing the improvement in muscle strength in participants who have trained with different levels of mental effort In addition to evaluating muscle strength this study will also examine the neural mechanisms underlying muscle strength improvements
Four groups of volunteers 65 years old and over will participate in a training program directed at elbow-flexor muscles One group will be trained with an intensity near the level of maximal voluntary contraction MVC group a second group will be trained with high mental effort low muscle intensity contractions HME group a third group will be trained with low mental effort low muscle intensity elbow-flexion contractions LME group and the fourth control group will not be trained but will participate in the strength tests Training will be performed every weekday for 12 weeks Participants will be evaluated by functional MRI fMRI EEG-derived motor activity-related cortical potential MRCP surface EMG signals and the MRI T2 relaxation time
Preliminary analysis of results shows that the HME group gained more than 13 strength the LME group showed a statistically insignificant 6 change and the no-practice control group did not show any change in elbow flexor muscle strength We expect the MVC group to have the highest strength gains among the four groups
This study will evaluate the relationship between mental effort muscle strength improvements by comparing the improvement in muscle strength in participants who have trained with different levels of mental effort In addition to evaluating muscle strength this study will also examine the neural mechanisms underlying muscle strength improvements
Four groups of volunteers 65 years old and over will participate in a training program directed at elbow-flexor muscles One group will be trained with an intensity near the level of maximal voluntary contraction MVC group a second group will be trained with high mental effort low muscle intensity contractions HME group a third group will be trained with low mental effort low muscle intensity elbow-flexion contractions LME group and the fourth control group will not be trained but will participate in the strength tests Training will be performed every weekday for 12 weeks Participants will be evaluated by functional MRI fMRI EEG-derived motor activity-related cortical potential MRCP surface EMG signals and the MRI T2 relaxation time
Preliminary analysis of results shows that the HME group gained more than 13 strength the LME group showed a statistically insignificant 6 change and the no-practice control group did not show any change in elbow flexor muscle strength We expect the MVC group to have the highest strength gains among the four groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None