Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001563
Status:
COMPLETED
Last Update Posted:
2022-01-19
First Post:
1999-11-03
Brief Title:
EPOCH Chemotherapy - IL-12 for Previously Untreated and EPOCH Plus Rituximab for Previously Treated Patients With AIDS-Associated Lymphoma
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
EPOCH Chemotherapy Plus Rituximab for Previously Treated Patients With AIDS-Associated Lymphoma
Status:
COMPLETED
Status Verified Date:
2022-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The prognosis of AIDS-related Non-Hodgkins lymphoma is poor especially in the relapsed setting There is no standard treatment and the few small studies that have been conducted have reported dismal outcomes The purpose of this study is to pilot the use of EPOCH plus rituximab in previously treated AIDS-related lymphoma Clinical endpoints of the study include toxicity and response Progression-free and overall survival will be measured Tumors will be evaluated for p53 mutations p-16 bcl-2 expression tumor proliferation c-myc and EBV when possible
Detailed Description:
The prognosis of AIDS-related Non-Hodgkins lymphoma is poor especially in the relapsed setting There is no standard treatment and the few small studies that have been conducted have reported dismal outcomes The purpose of this study is to pilot the use of EPOCH plus rituximab in previously treated AIDS-related lymphoma Clinical endpoints of the study include toxicity and response Progression-free and overall survival will be measured Tumors will be evaluated for p53 mutations p-16 bcl-2 expression tumor proliferation c-myc and EBV when possible
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 97-C-0040 | None | None | None |