Ignite Creation Date:
2024-05-05 @ 11:29 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00056914
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2003-03-26
Brief Title:
Development of Techniques for Use in MRI With a Magnetic Field of 7 Tesla
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Development of 7 Tesla MRI Methodology for Anatomical Functional and Spectroscopic Imaging of the Brain
Status:
COMPLETED
Status Verified Date:
2010-01-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will develop new techniques for optimizing resolution in magnetic resonance imaging MRI with a high magnetic field of 7 Tesla MRI is a diagnostic tool that generates high-quality images of the body without the use of x-rays It can also provide information about brain chemistry and physiology The test is routinely done at magnetic field strengths of from 15 to 4 Tesla This study will use an investigational device that operates at a high magnetic field of 7 Tesla Except for the increase in magnetic field all other aspects of imaging are the same as those at lower magnetic fields This study will use techniques in conjunction with the higher magnetic field that may improve diagnostic imaging The MRI will monitor the brain at high resolution to see structural features to measure brain chemicals and to determine how much and how fast blood flows into brain regions in response to simple tasks
Healthy normal volunteers 18 years of age and older may participate in this study Candidates will be screened with a medical history neurological examination and questionnaire
Participants will have a standard 15 or 3 Tesla MRI before the 7 Tesla scan adding about 5 minutes to the procedure The procedure for both scans is the same The subject lies on a table that is moved into the scanner Because the machine makes loud sounds during the imaging earplugs are provided to help reduce the noise An insulated wire coil may be placed around the subjects head to obtain better images Scanning time varies from 20 minutes to 3 hours with most examinations lasting between 45 and 90 minutes During the scan the subject may be asked to perform simple tasks such as listening to tones tapping fingers moving a hand watching a movie on a screen or smelling pleasant odors More complex tasks may require thinking about tones or pictures and responding to them by pressing buttons Following the test subjects will complete a brief questionnaire about comfort level and any unusual sensations they may have experienced during the test
Participants who undergo repeated MRIs for the evaluation of new techniques will have a standard 15 or 3 Tesla MRI brain study once a year while participating in the research protocol A radiologist at NIH will read the MRIs and if any abnormalities are discovered the individual will be referred to his or her private physician or to a consult service at NIH
Healthy normal volunteers 18 years of age and older may participate in this study Candidates will be screened with a medical history neurological examination and questionnaire
Participants will have a standard 15 or 3 Tesla MRI before the 7 Tesla scan adding about 5 minutes to the procedure The procedure for both scans is the same The subject lies on a table that is moved into the scanner Because the machine makes loud sounds during the imaging earplugs are provided to help reduce the noise An insulated wire coil may be placed around the subjects head to obtain better images Scanning time varies from 20 minutes to 3 hours with most examinations lasting between 45 and 90 minutes During the scan the subject may be asked to perform simple tasks such as listening to tones tapping fingers moving a hand watching a movie on a screen or smelling pleasant odors More complex tasks may require thinking about tones or pictures and responding to them by pressing buttons Following the test subjects will complete a brief questionnaire about comfort level and any unusual sensations they may have experienced during the test
Participants who undergo repeated MRIs for the evaluation of new techniques will have a standard 15 or 3 Tesla MRI brain study once a year while participating in the research protocol A radiologist at NIH will read the MRIs and if any abnormalities are discovered the individual will be referred to his or her private physician or to a consult service at NIH
Detailed Description:
The goal of this protocol is to optimize new technology that enables Magnetic Resonance Imaging MRI at a static magnetic field strength of 7 Tesla 7T Techniques will be developed for anatomical functional and spectroscopic MRI that can take advantage of this high field Routine clinical MRI has been performed at 15T for over twenty years and over the past ten years MRI at 3-4T has demonstrated large increases in sensitivity and is beginning to find widespread application for functional imaging of the brain and clinical research Since the late 1990s it has been possible to produce magnets with field strengths between 7-9T large enough for human use Indeed there are presently two sites with 7T and one with 8T MRI that have begun to produce exciting images These initial results confirm that MRI can be performed safely at these high field strengths and that the whole range of MRI experiments can be performed We will take delivery of the first 7T MRI system produced by General Electric the leading producer of MRI equipment sometime in late 2002early 2003
Compared to 3-4T the 7T scanner is expected to improve sensitivity by a factor of two and improve contrast to noise for functional imaging and spectroscopy by a factor of two - four However realizing these goals for routine practice and whole brain coverage will require technical developments and integrating these developments into optimized data acquisition and processing strategies Therefore we plan to extend parallel imaging strategies currently becoming available for 3T MRI to 7T in order to realize the full gain in sensitivity and apply these techniques to obtain high resolution anatomical MRI generate high temporal and spatial resolution perfusion images using arterial spin labeling techniques generate high-temporal and spatial resolution functional images of the brain using blood oxygenation BOLD and perfusion based techniques and test the usefulness of 7T for spectroscopic studies of metabolites of the brain All of these developments will be performed on normal healthy volunteers
Compared to 3-4T the 7T scanner is expected to improve sensitivity by a factor of two and improve contrast to noise for functional imaging and spectroscopy by a factor of two - four However realizing these goals for routine practice and whole brain coverage will require technical developments and integrating these developments into optimized data acquisition and processing strategies Therefore we plan to extend parallel imaging strategies currently becoming available for 3T MRI to 7T in order to realize the full gain in sensitivity and apply these techniques to obtain high resolution anatomical MRI generate high temporal and spatial resolution perfusion images using arterial spin labeling techniques generate high-temporal and spatial resolution functional images of the brain using blood oxygenation BOLD and perfusion based techniques and test the usefulness of 7T for spectroscopic studies of metabolites of the brain All of these developments will be performed on normal healthy volunteers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-N-0142 | None | None | None |