Ignite Creation Date:
2024-05-05 @ 11:29 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00055380
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2003-02-28
Brief Title:
Chemical and Genetic Effects of the Experimental Anti-Cancer Drugs in Cheek Cells in Cancer Patients
Sponsor:
National Institute of Dental and Craniofacial Research NIDCR
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Molecular Genetic and Biochemical Effects Of Novel Therapies In Buccal Mucosal Cells
Status:
COMPLETED
Status Verified Date:
2005-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine the effects of certain investigational anti-cancer drugs on the genetic and protein makeup of cells The findings will be entered into a database that may be used to 1 determine the optimal dose of drug that will provide the most benefit with the least harmful side effects and 2 predict which patients will have a greater chance of developing side effects or a greater chance of benefiting from the drug
Patients 18 years of age and older who are receiving the anti-cancer drugs flavopiridol or perifosine in an NIH clinical trial may be eligible for this study
Participants will undergo the following procedures both before starting treatment and during the first treatment cycle to look for genetic or chemical changes produced in response to the study drug
Blood draws
Buccal cell brushings Collection of buccal cells cells lining the inside of the cheeks from the inside of the cheeks using a soft bristle brush for a few seconds several times The patient then rinses the mouth with salt water for 1 minute and then spits into a cup
Buccal cell biopsies on both sides of the mouth For this procedure a local anesthetic is given to numb the biopsy area Then a small piece of tissue from the inner lining of the mouth is removed with a small sharp cookie-cutter instrument The biopsy findings will be compared with those of the cheek brushings to see if the information is similar
Tumor biopsies In patients whose tumor is easily accessible such as the skin abdominal fluid tissue biopsies will be requested Depending on the type and location of the tumor the biopsy may be done with a forceps a large needle needle biopsy a cookie-cutter instrument punch biopsy or a small knife excisional biopsy All of these procedures are done with a local anesthetic
Patients 18 years of age and older who are receiving the anti-cancer drugs flavopiridol or perifosine in an NIH clinical trial may be eligible for this study
Participants will undergo the following procedures both before starting treatment and during the first treatment cycle to look for genetic or chemical changes produced in response to the study drug
Blood draws
Buccal cell brushings Collection of buccal cells cells lining the inside of the cheeks from the inside of the cheeks using a soft bristle brush for a few seconds several times The patient then rinses the mouth with salt water for 1 minute and then spits into a cup
Buccal cell biopsies on both sides of the mouth For this procedure a local anesthetic is given to numb the biopsy area Then a small piece of tissue from the inner lining of the mouth is removed with a small sharp cookie-cutter instrument The biopsy findings will be compared with those of the cheek brushings to see if the information is similar
Tumor biopsies In patients whose tumor is easily accessible such as the skin abdominal fluid tissue biopsies will be requested Depending on the type and location of the tumor the biopsy may be done with a forceps a large needle needle biopsy a cookie-cutter instrument punch biopsy or a small knife excisional biopsy All of these procedures are done with a local anesthetic
Detailed Description:
A significant problem in drug development of novel small molecules is the lack of available tissues surrogate tissues that allow for the assessment of the molecular and biochemical effects of targeted-therapies drug action The information obtained from surrogate tissues might help us validate previous preclinical studies with those agents and also dose them in a more rational way Oral keratinocytes which are accessible by non-invasive means might be useful to assess drug action The proposed study seeks to investigate the genetic molecular and biochemical effects of novel agents in oral buccal mucosal cells Patients already enrolled in Phase I and II clinical trials for neoplastic diseases at the Clinical Center will undergo oral cytobrushing before and during therapy to determine the molecular and biochemical effects of novel agents in the oral mucosa cells Similar studies will be performed in peripheral blood mononuclear cells In order to validate to compare and compare the oral cytobrush methodology some of these subjects will undergo oral punch biopsy studies Some of these subjects will also undergo tumor biopsy if accessible or available
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-D-0115 | None | None | None |