Ignite Creation Date:
2024-05-05 @ 11:29 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00050024
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2002-11-19
Brief Title:
Transcranial Magnetic Stimulation and Electrical Stimulation of Nerves to Study Focal Dystonia
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
The Effect of Peripheral Heterotopic Stimulation on Cortical Excitability in Dystonia
Status:
COMPLETED
Status Verified Date:
2008-09-17
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use transcranial magnetic stimulation TMS and electrical stimulation of nerves to examine how the brain controls muscle movement in focal hand dystonia writers cramp Normally when a person moves a finger the brains motor cortex prevents the other fingers from moving involuntarily Patients with focal hand dystonia have difficulty with individualized finger movements possibly due to increased excitability of the motor cortex Musicians writers typists athletes and others whose work involves frequent repetitive movements may develop focal dystonia of the hand
Healthy normal volunteers and patients with focal dystonia 18 years of age and older may be eligible for this study
For the TMS procedure subjects are seated in a comfortable chair with their hands placed on a pillow on their lap An insulated wire coil is placed on the scalp A brief electrical current is passed through the coil creating a magnetic pulse that stimulates the brain This may cause muscle hand or arm twitching if the coil is near the part of the brain that controls movement or it may induce twitches or transient tingling in the forearm head or face muscles Subjects will be asked to move a finger Just before this movement a brief electrical stimulation will be applied to the end of either the second or fifth finger Metal electrodes will be taped to the skin over the muscle for computer recording of the electrical activity of the hand and arm muscles activated by the stimulation The testing will last 2-3 hours
Healthy normal volunteers and patients with focal dystonia 18 years of age and older may be eligible for this study
For the TMS procedure subjects are seated in a comfortable chair with their hands placed on a pillow on their lap An insulated wire coil is placed on the scalp A brief electrical current is passed through the coil creating a magnetic pulse that stimulates the brain This may cause muscle hand or arm twitching if the coil is near the part of the brain that controls movement or it may induce twitches or transient tingling in the forearm head or face muscles Subjects will be asked to move a finger Just before this movement a brief electrical stimulation will be applied to the end of either the second or fifth finger Metal electrodes will be taped to the skin over the muscle for computer recording of the electrical activity of the hand and arm muscles activated by the stimulation The testing will last 2-3 hours
Detailed Description:
The purpose of this study is to investigate the effect of sensory afferent input on surround inhibition in the motor cortex in dystonia Surround inhibition is a cortical phenomenon the function of which may be to suppress unwanted movements in surrounding muscles during voluntary actions In support of this a recent study showed that motor output to the little finger was reduced during self-paced voluntary movements of the index finger despite an increase in spinal excitability Work has also shown that in relaxed muscles homotopic and heterotopic peripheral stimulation results in time dependent modulation of motor cortical excitability However no studies have examined the relationship between volitional movement and sensory input on cortical surround inhibition the phenomenon which we hypothesize to be defective in dystonia The aim of this study then is to examine the changes in surround inhibition when electrical stimulation is applied to the finger being actively moved leading to an inhibition of a surrounding finger heterotopic inhibition at different time intervals prior to the initiation of movement to assess the effect of heterotopic peripheral stimulation on surround inhibition in dystonia patients compared to normal subjects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-N-0048 | None | None | None |