Ignite Creation Date:
2024-05-05 @ 10:26 PM
Last Modification Date:
2024-10-26 @ 10:18 AM
Study NCT ID:
NCT01108133
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2010-04-20
Brief Title:
Neural and Pharmacological Correlates of Intrusions in Patients With Posttraumatic Stress Disorder
Sponsor:
Central Institute of Mental Health Mannheim
Organization:
Central Institute of Mental Health Mannheim
Study Overview
Official Title:
Neural and Pharmacological Correlates of Intrusions in Patients With Posttraumatic Stress Disorder
Status:
COMPLETED
Status Verified Date:
2016-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
There is evidence that glucocorticoids have an impact on intrusive memories in patients with posttraumatic stress disorder PTSD Hydrocortisone impairs intrusive memory retrieval whereas dexamethasone should strengthen intrusions in PTSD We the investigators want to investigate 1 the effect of these two glucocorticoids on traumatic memories and 2 assess the neural correlates using the script-driven imagery paradigm in the functional magnetic resonance imaging fMRI scanner We hypothesize that intrusive memories are less intensive under hydrocortisone-administration and more intense under dexamethasone-administration comparing both to a placebo-condition Regarding the neural activation pattern we expect higher activation in the hydrocortisone condition in the amygdala the hippocampus and the medial prefrontal cortex compared to the placebo-condition and less activation in the dexamethasone-condition compared to the placebo-condition
Detailed Description:
There is evidence that glucocorticoids have an impact on intrusive memories in patients with posttraumatic stress disorder PTSD Hydrocortisone impairs intrusive memory retrieval whereas dexamethasone should strengthen intrusions in PTSD We the investigators want to investigate 1 the effect of these two glucocorticoids on traumatic memories and 2 assess the neural correlates using the script-driven imagery paradigm in the functional magnetic resonance imaging fMRI scanner Therefore an individual trauma-and an individual neutral -script is assessed from each participant recorded and replayed during fMRI-scanning We hypothesize that intrusive memories are less intense under hydrocortisone-administration and more intense under dexamethasone-administration comparing both to a placebo-condition Regarding the neural activation pattern we expect higher activation in the hydrocortisone condition in the amygdala the hippocampus and the medial prefrontal cortex compared to the placebo-condition and less activation in the dexamethasone-condition compared to the placebo-condition
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| GC-fMRI-PTSD-2010 | OTHER | Intern | None |