Ignite Creation Date:
2025-12-25 @ 12:14 AM
Ignite Modification Date:
2025-12-25 @ 10:16 PM
Study NCT ID:
NCT04327258
Status:
COMPLETED
Last Update Posted:
2020-03-31
First Post:
2020-03-26
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels
Sponsor:
Insel Gruppe AG, University Hospital Bern
Organization:
Study Overview
Official Title:
The Influence of NPPA/NPPB Haplotype on Natriuretic Peptide Plasma Levels
Status:
COMPLETED
Status Verified Date:
2020-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Crosssectional study to analyse the genetic influence on levels of cardiac biomarkers (BNP, NT-proBNP).
Detailed Description:
Background
Natriuretic peptides play an important role in risk stratification and management of patients undergoing non-cardiac surgery. However, due to genetic variability, the levels of these biomarkers may differ in individual patients with cardiac derangement. In the preoperative setting, genetic contribution to natriuretic peptide plasma level variability has not yet been determined.
Objective
The aim of this study is to assess genetic contribution to NP plasma level variability in a Swiss cohort.
Methods
Cross-sectional association study in a cohort of non-cardiac surgery patients.
This study is a Subproject of a prospective cohort study registered under the ID 041/09.
Natriuretic peptides play an important role in risk stratification and management of patients undergoing non-cardiac surgery. However, due to genetic variability, the levels of these biomarkers may differ in individual patients with cardiac derangement. In the preoperative setting, genetic contribution to natriuretic peptide plasma level variability has not yet been determined.
Objective
The aim of this study is to assess genetic contribution to NP plasma level variability in a Swiss cohort.
Methods
Cross-sectional association study in a cohort of non-cardiac surgery patients.
This study is a Subproject of a prospective cohort study registered under the ID 041/09.
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: