Ignite Creation Date:
2024-05-05 @ 11:29 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00053521
Status:
COMPLETED
Last Update Posted:
2016-11-06
First Post:
2003-01-30
Brief Title:
Genetic Epidemiology of CVD Risk Factors
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2008-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine the role of genetic factors influencing risk factors for cardiovascular disease ultimately identifying specific genes influencing the age-related progression of cardiovascular disease risks
Detailed Description:
BACKGROUND
Understanding the genetic basis of common multifactorial diseases such as cardiovascular disease CVD remains an elusive goal but the great advances in molecular genetic technology statistical genetic methods and phenotypic assessment of CVD risk factors in recent years have facilitated more sophisticated genetic studies of risks for heart disease
The study is a follow-up to one conducted in the 1970s and 1980s The availability of 5 large kindreds first identified and recruited as part of the High Blood Pressure in the Young program is an important resource The investigators have an extensive array of baseline data that was collected in the late 1970s and early 1980s on 750 participants stemming from that project although some data are available only on a subset of participants The present study population centers on 764 individuals in five large multigenerational extended families four white and one African-American originally examined 25 years ago Data collected from the original participants include hundreds of biochemical medical physiological behavioral physical psychological genetic and demographic traits
DESIGN NARRATIVE
The study consists of four specific aims 1 Collect 25-year follow-up data from approximately 500 of the original participants and new data from approximately 500 of their relatives not examined in the original study The cardiovascular disease risk factor phenotypes to be collected include hemodynamic measures carotid intima-media thickness and measures of cardiopulmonary function 2 Obtain DNA samples from these 1000 individuals and use modern high-throughput molecular genotyping methods to create a 10 cM genetic marker map 3 Quantify and characterize the nature of genetic influences on CVD risk factors using quantitative genetic methods suited for cross-sectional and serial follow-up data from relatives in large extended families 4 Conduct linkage analyses to identify chromosomal regions QTLs harboring genes that influence individual variation in cardiovascular disease risk factors Following these linkage analyses the investigators will examine more closely the strongest linkage signals with fine mapping linkage analysis in order to narrow chromosomal regions of interest The study is a collaboration between Wright State University and the Southwest Foundation for Biomedical Research
Understanding the genetic basis of common multifactorial diseases such as cardiovascular disease CVD remains an elusive goal but the great advances in molecular genetic technology statistical genetic methods and phenotypic assessment of CVD risk factors in recent years have facilitated more sophisticated genetic studies of risks for heart disease
The study is a follow-up to one conducted in the 1970s and 1980s The availability of 5 large kindreds first identified and recruited as part of the High Blood Pressure in the Young program is an important resource The investigators have an extensive array of baseline data that was collected in the late 1970s and early 1980s on 750 participants stemming from that project although some data are available only on a subset of participants The present study population centers on 764 individuals in five large multigenerational extended families four white and one African-American originally examined 25 years ago Data collected from the original participants include hundreds of biochemical medical physiological behavioral physical psychological genetic and demographic traits
DESIGN NARRATIVE
The study consists of four specific aims 1 Collect 25-year follow-up data from approximately 500 of the original participants and new data from approximately 500 of their relatives not examined in the original study The cardiovascular disease risk factor phenotypes to be collected include hemodynamic measures carotid intima-media thickness and measures of cardiopulmonary function 2 Obtain DNA samples from these 1000 individuals and use modern high-throughput molecular genotyping methods to create a 10 cM genetic marker map 3 Quantify and characterize the nature of genetic influences on CVD risk factors using quantitative genetic methods suited for cross-sectional and serial follow-up data from relatives in large extended families 4 Conduct linkage analyses to identify chromosomal regions QTLs harboring genes that influence individual variation in cardiovascular disease risk factors Following these linkage analyses the investigators will examine more closely the strongest linkage signals with fine mapping linkage analysis in order to narrow chromosomal regions of interest The study is a collaboration between Wright State University and the Southwest Foundation for Biomedical Research
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL069995-01 | NIH | None | httpsreporternihgovquickSearchR01HL069995-01 |
| R01HL070167-01 | NIH | None | None |