Ignite Creation Date:
2024-05-05 @ 10:26 PM
Last Modification Date:
2024-10-26 @ 10:18 AM
Study NCT ID:
NCT01106794
Status:
RECRUITING
Last Update Posted:
2023-02-10
First Post:
2010-04-19
Brief Title:
Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma
Sponsor:
Childrens National Research Institute
Organization:
Childrens National Research Institute
Study Overview
Official Title:
Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to prospectively collect specimens from pediatric patients with diffuse intrinsic pontine glioma or brainstem glioma either during therapy or at autopsy in order to characterize the molecular abnormalities of this tumor
Detailed Description:
High grade diffuse intrinsic pontine glioma DIPG accounts for approximately 80 of pediatric brainstem tumors and 10 of pediatric brain tumors and is the most lethal form of brainstem gliomas in children There is currently no effective therapy to treat these tumors We hypothesize that this tumor exhibits unique molecular abnormalities leading to altered RNA and protein expression The aim of this trial is to collect specimens from pediatric patients with diffuse intrinsic pontine glioma including serum cerebrospinal fluid urine brain tumor and other constitutional tissue during therapy andor at autopsy Our goal is to study this tissue to characterize the genetic abnormalities that lead to tumor formation in order to identify key molecules as biomarkers which we can target to design and test new and more effective treatments
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None