Ignite Creation Date:
2024-05-05 @ 11:29 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00055289
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2003-02-22
Brief Title:
Brain Use of Sensory Information to Generate Movement
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Role of Multimodal Areas for Sensory-To-Motor Processing
Status:
COMPLETED
Status Verified Date:
2006-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use transcranial magnetic stimulation TMS to investigate functions of brain regions that may use information from sensory organs such as the eyes or ears to generate movements
For TMS a wire coil is held over the scalp A brief electrical current is passed through the coil creating a magnetic pulse that stimulates the brain This may cause a pulling sensation on the skin under the coil and twitching in muscles of the face arm or leg During the stimulation the participant may be asked to tense certain muscles slightly or perform other simple actions
Healthy normal volunteers 18 years of age and older may be eligible for this study Individuals with a history of neuropsychiatric disorders brain lesions such as tumors stroke or trauma or a history of significant medical disorders such as cancer may not participate Candidates will be screened with a medical history brief physical examination and questionnaire
Participants will be presented a sequence of shapes circles rectangles and triangle and will count the number of a specified shape Each number is assigned to a corresponding response button The subject will push the appropriate button with the corresponding finger During these experiments the scalp will be stimulated by TMS Each set of TMS measurements will take up to 3-12 hours
For TMS a wire coil is held over the scalp A brief electrical current is passed through the coil creating a magnetic pulse that stimulates the brain This may cause a pulling sensation on the skin under the coil and twitching in muscles of the face arm or leg During the stimulation the participant may be asked to tense certain muscles slightly or perform other simple actions
Healthy normal volunteers 18 years of age and older may be eligible for this study Individuals with a history of neuropsychiatric disorders brain lesions such as tumors stroke or trauma or a history of significant medical disorders such as cancer may not participate Candidates will be screened with a medical history brief physical examination and questionnaire
Participants will be presented a sequence of shapes circles rectangles and triangle and will count the number of a specified shape Each number is assigned to a corresponding response button The subject will push the appropriate button with the corresponding finger During these experiments the scalp will be stimulated by TMS Each set of TMS measurements will take up to 3-12 hours
Detailed Description:
The role of multimodal brain regions for sensory-to-motor processing is not well understood In our recent neuroimaging study with fMRI we found that multimodal areas such as the right superior temporal cortex and right dorsal premotor cortex were activated during sensory instructed movements These regions might contribute to extract common features or concepts from sensory stimuli but we do not have firm experimental evidence yet In order to investigate the functional roles of multimodal brain regions further we propose to apply a transcranial magnetic stimulation TMS technique TMS can create transient brain lesions allowing functional mapping of cortical regions In this protocol by stimulating the multimodal areas using TMS we will determine the functional role of these areas
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-N-0112 | None | None | None |