Ignite Creation Date:
2024-05-05 @ 10:22 PM
Last Modification Date:
2024-10-26 @ 10:18 AM
Study NCT ID:
NCT01099410
Status:
COMPLETED
Last Update Posted:
2016-01-06
First Post:
2010-03-30
Brief Title:
Apoptotic Cell AC Uptake by Human Alveolar Macrophages AM
Sponsor:
VA Office of Research and Development
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Apoptotic Cell Ingestion by Normal Human Alveolar Macrophages
Status:
COMPLETED
Status Verified Date:
2016-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to compare the ability of two types of white blood cells to eat dead host cells and how this process affects their ability to protect the body from infection The two cell types are monocytes a cell in the bloodstream and alveolar macrophages a cell in the lung that is ultimately derived from monocytes
Detailed Description:
Volunteers who may be Veterans or non-Veterans will be screened by a series of questionnaires chest X-ray spirometry EKG blood work and a complete history and physician examination by a study physician Those who qualify for the study and agree via informed consent will undergo a fiberoptic bronchoscopy on a separate day for the initial visit Bronchoscopy is a procedure in which a flexible video instrument is passed via the nose or mouth through the vocal cords and into the lungs During the procedure portions of the lungs will be washed lavaged with a salt water solution to collect the alveolar macrophages This procedure involves conscious sedation so that a driver is required on the day of the bronchoscopy The entire procedure including placement of an intravenous line to administer medications local anesthetics the bronchoscopy itself and the recovery period takes about 25-3 hours The cells collected by bronchoscopy will be studied in the research laboratory and used entirely in that procedure
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None