Ignite Creation Date:
2024-05-05 @ 11:28 AM
Last Modification Date:
2024-10-26 @ 9:08 AM
Study NCT ID:
NCT00055172
Status:
RECRUITING
Last Update Posted:
2024-07-15
First Post:
2003-02-20
Brief Title:
Genetic Basis of Immunodeficiency
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
The Determination of Genetic Basis Of Immunodeficiency
Status:
RECRUITING
Status Verified Date:
2024-02-20
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine the role of hereditary factors in different forms of severe combined immunodeficiency SCID
Patients with immunodeficiencies may be eligible for this study Candidates include
Patients with diminished numbers of T cells or NK cells or both or
Patients with normal T cell and NK cell numbers but diminished T cell B cell or NK cell function
Relatives of patients will also be studied
Participants will have blood samples collected for genetic analysis in studies related to SCID at the National Institutes of Health and other institutions
Patients with immunodeficiencies may be eligible for this study Candidates include
Patients with diminished numbers of T cells or NK cells or both or
Patients with normal T cell and NK cell numbers but diminished T cell B cell or NK cell function
Relatives of patients will also be studied
Participants will have blood samples collected for genetic analysis in studies related to SCID at the National Institutes of Health and other institutions
Detailed Description:
The goal of this project is to identify the genetic basis of new forms of inherited immunodeficiency The particular focus relates to cytokines such as IL-2 IL-4 IL-7 IL-9 IL-15 and IL-21 that share the common cytokine receptor Gamma chain Gamma c and to molecules that are important for signaling or gene regulation in response to these cytokines although other causes of inherited immunodeficiency are also encompassed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 03-H-0105 | None | None | None |