Ignite Creation Date:
2024-05-05 @ 10:21 PM
Last Modification Date:
2024-10-26 @ 10:17 AM
Study NCT ID:
NCT01085149
Status:
UNKNOWN
Last Update Posted:
2010-03-11
First Post:
2010-03-10
Brief Title:
The Effect Of Simvastatin On Bone Remodeling In Socket Of Mandibular Teeth
Sponsor:
Hadassah Medical Organization
Organization:
Hadassah Medical Organization
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2010-03
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Simvastatin has been reported to promote osteoblastic activity and inhibit osteoclastic activity by enhancing the expression of BMP2 There have been many studies demonstrating the bone-promoting effect of local application various animal models including after application into socket of teeth in a rat the purpose of the study is to investigate the effect of slow release topical simvastatin in socket of mandibular teeth on bone remodeling in the socket
Detailed Description:
after extraction of mandibular single root teeth 10 mg of slow release simvastatin would be inserted to the socket observation will be at 1 week 4 weeks and 3 monthsafter 3 months the patients will have dental CT as done routinely in our clinic before placing dental implants and the bone density and height will be measured on this data during the procedure of inserting a dental implant a trephine will be taken for histology
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None