Ignite Creation Date:
2024-05-05 @ 10:18 PM
Last Modification Date:
2024-10-26 @ 10:16 AM
Study NCT ID:
NCT01073410
Status:
COMPLETED
Last Update Posted:
2022-02-01
First Post:
2010-02-19
Brief Title:
Chitinases and Transforming Growth Factor Beta TGFB in Human Asthma
Sponsor:
University of California San Francisco
Organization:
University of California San Francisco
Study Overview
Official Title:
Chitinases and TGFB in Human Asthma
Status:
COMPLETED
Status Verified Date:
2022-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AADCRC
Brief Summary:
The purpose of this study is to find out the roles of two specific gene families the chitinase gene family and the TGFB family We hypothesize that chitinases and TGFb pathway genes will be differentially expressed in the airways of non-asthmatic subjects and subjects with asthma We further hypothesize that genetic variants in CHIT1 AMCase and TGFb pathway genes that show associations with asthma and related phenotypes will change the expression andor function of the protein of these genes in the airway in several ways including the transcript numbers for full length genes and splice variants and for the chitinase genes the levels of chitinase activity in airway secretions
Detailed Description:
This is a cross-sectional study in patients with asthma and healthy controls in which we will analyze how the expression or function of CHIT1 AMCase and TGFb pathway genes in the asthmatic airway is affected by genetic variation in these genes We propose detailed phenotyping of the asthmatic subjects and the healthy controls including collection of induced sputum exhaled air and detailed physiologic measures including measures of airflow lung volumes and methacholine responsiveness as well as collection of airway cells and tissues by bronchoscopy We will determine the relative expression of CHIT1 and AMCase in specific lung compartments large airways small airways epithelial cells macrophages and the effects of genetic variants in CHIT1 and AMCase on expression of splice variants and levels of chitinase activity in the airway These human samples will also allow us to determine if any of the multiple TGFb pathway genes analyzed show differential expression in the lung in asthma
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U19AI077439 | NIH | None | httpsreporternihgovquickSearchU19AI077439 |