Ignite Creation Date:
2024-05-05 @ 10:16 PM
Last Modification Date:
2024-10-26 @ 10:16 AM
Study NCT ID:
NCT01077895
Status:
WITHDRAWN
Last Update Posted:
2022-12-15
First Post:
2010-02-25
Brief Title:
The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration CVVH on Intra-abdominal Pressure and Kidney Function
Sponsor:
University Hospital Ghent
Organization:
University Hospital Ghent
Study Overview
Official Title:
The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration CVVH on Intra-abdominal Pressure and Kidney Function in Critically Ill Adults With Intra-abdominal Hypertension and Acute Kidney Injury
Status:
WITHDRAWN
Status Verified Date:
2022-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Intra- abdominal hypertension IAH and abdominal compartment syndrome ACS are a cause of organ dysfunction in critically ill patients IAH develops due to abdominal lesions primary IAH or extra-abdominal processes secondary IAH Secondary IAH arises due to decreased abdominal wall compliance and gut edema caused by capillary leak and excessive fluid resuscitation Decreasing intra-abdominal pressure IAP using decompressieve laparotomy has been shown to improve organ dysfunction However laparotomy is generally avoided in patients with secondary IAH due to the risk of abdominal complications
Acute kidney injury AKI is one of the first and most pronounced organ failures associated with IAH and many patients with AKI in the ICU require renal replacement therapy RRT Fluid removal using continuous RRT CRRT has been demonstrated to decrease IAP in small series and selected patients
The aim of this study is to evaluate whether fluid removal using CVVH in patients with IAH fluid overload and AKI is feasible and whether it has a beneficial effect on organ dysfunction compared to CVVH without net fluid removal
Acute kidney injury AKI is one of the first and most pronounced organ failures associated with IAH and many patients with AKI in the ICU require renal replacement therapy RRT Fluid removal using continuous RRT CRRT has been demonstrated to decrease IAP in small series and selected patients
The aim of this study is to evaluate whether fluid removal using CVVH in patients with IAH fluid overload and AKI is feasible and whether it has a beneficial effect on organ dysfunction compared to CVVH without net fluid removal
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None