Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001324
Status:
COMPLETED
Last Update Posted:
2021-03-16
First Post:
1999-11-03
Brief Title:
PET Scan to Study Brain Control of Human Movement
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
CNS Control of Human Movement H215O PET Studies
Status:
COMPLETED
Status Verified Date:
2000-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Positron Emission Tomography PET is a technique used to investigate activity in areas of the brain The PET technique allows researchers to study the normal processes in the brain central nervous system of normal individuals and patients with neurologic illnesses without physical structural damage to the brain
When a region of the brain is active it uses more fuel in the form of oxygen and sugar glucose As the brain uses more fuel it produces more waste products carbon dioxide and water Blood carries fuel to the brain and waste products away from the brain As brain activity increases blood flow to and from the area of activity also increases This is known as regional cerebral blood flow rCBF Knowing these facts researchers can use radioactive water H215O and PET scans to observe what areas of the brain are receiving more blood flow
In this study researchers plan to investigate the changes in regional cerebral blood flow rCBF as patients participate in different activities The activities are designed to stimulate the areas of the brain responsible for voluntary motor activity and sensation By comparing the results of PET scans performed in different conditions researchers can locate regions of the brain responsible for specific tasks
This study should provide new information about voluntary movements in humans and the preparation involved in controlling them
When a region of the brain is active it uses more fuel in the form of oxygen and sugar glucose As the brain uses more fuel it produces more waste products carbon dioxide and water Blood carries fuel to the brain and waste products away from the brain As brain activity increases blood flow to and from the area of activity also increases This is known as regional cerebral blood flow rCBF Knowing these facts researchers can use radioactive water H215O and PET scans to observe what areas of the brain are receiving more blood flow
In this study researchers plan to investigate the changes in regional cerebral blood flow rCBF as patients participate in different activities The activities are designed to stimulate the areas of the brain responsible for voluntary motor activity and sensation By comparing the results of PET scans performed in different conditions researchers can locate regions of the brain responsible for specific tasks
This study should provide new information about voluntary movements in humans and the preparation involved in controlling them
Detailed Description:
The main purpose of the studies presented in this protocol is to investigate the physiology of motor control in health as well as the pathophysiological modifications taking place during disease To this end we will investigate changes in regional cerebral blood flow rCBF as an index of regional neuronal activity associated with various motor and sensory tasks using Positron Emission Tomography PET The rCBF will be obtained by measuring the distribution of the cerebral radioactivity during emission scans following the intravenous bolus injection of 15O-labeled water The very short half-life of 15O 2 minutes allows us to measure rCBF repeatedly under different task conditions see methodology and experimental procedures With the comparison between PET scans performed in different conditions we can detect the specific task-related activated regions PET images will be coregistered to high resolution Magnetic Resonance Images MRI to get more accurate anatomical information regarding the activated areas The results will be correlated with that from other physiological approaches including Electroencephalography EEG Transcranial Magnetic Stimulation TMS functional Magnetic Resonance Imaging fMRI and Magnetic Resonance Spectroscopy MRS These studies should provide new information not only about the executive component of the voluntary movements in humans but also the different organizational aspects of the preparatory processes that control them
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 92-N-0119 | None | None | None |