Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006398
Status:
COMPLETED
Last Update Posted:
2017-06-01
First Post:
2000-10-05
Brief Title:
Prevention of Esophageal Varices by Beta-Adrenergic Blockers
Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Organization:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Study Overview
Official Title:
Randomized Double-Blind Study of Timolol A Nonselective Beta-Adrenergic Blocker vs Placebo to Prevent Complications of Hepatic Portal Hypertension in Patients With Cirrhosis
Status:
COMPLETED
Status Verified Date:
2017-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to learn whether timolol is useful in preventing or delaying the appearance of gastroesophageal varices a complication that may develop in the future as a consequence of liver disease Cirrhosis causes an increased resistance of blood flowing through the liver This leads to an increased pressure in the portal vein the vein that takes blood to your liver High portal pressure is responsible for the appearance of complications of chronic liver disease such as varices and variceal bleeding bleeding from veins in your esophagus Timolol belongs to a group of medications called beta-blockers Beta-blockers decrease high portal pressure and previous studies have shown that beta-blocker pills are useful in preventing bleeding from varices in patients who already have varices A more desirable effect would be if these pills could prevent not only bleeding from varices but the appearance of varices and therefore of bleeding
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| YALESM 6618 | OTHER | Yale School of Medicine | httpsreporternihgovquickSearchR01DK046580 |
| R01DK046580 | NIH | None | None |