Ignite Creation Date:
2024-05-05 @ 10:12 PM
Last Modification Date:
2024-10-26 @ 10:15 AM
Study NCT ID:
NCT01057199
Status:
COMPLETED
Last Update Posted:
2015-05-07
First Post:
2010-01-26
Brief Title:
Studying Biomarkers in Cell Samples From Patients With Acute Myeloid Leukemia
Sponsor:
Childrens Oncology Group
Organization:
Childrens Oncology Group
Study Overview
Official Title:
Critical Role of MicroRNA-34a and MicroRNA-194 in Acute Myeloid Leukemia With CEBPA Mutations
Status:
COMPLETED
Status Verified Date:
2015-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
RATIONALE Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer
PURPOSE This research study is looking at biomarkers in cell samples from patients with acute myeloid leukemia
PURPOSE This research study is looking at biomarkers in cell samples from patients with acute myeloid leukemia
Detailed Description:
OBJECTIVES
To determine the significance of regulation of microRNA-34a and microRNA-194 by CEBPα during granulopoiesis in patients with acute myeloid leukemia with CEBPA mutations
To determine whether overexpression of micro RNA-34a and microRNA-194 in myeloid progenitors with CEBPα mutations leads to granulocytic differentiation
To examine how microRNA-34a and microRNA-194 downregulate E2F3 during granulopoiesis
To determine the role of microRNA-34a and microRNA-194 in myeloid cell proliferation
OUTLINE Cryopreserved cell samples are collected for laboratory analysis including mutation analysis gene expression analysis RNA analysis and fluorescence-activated cell sorting FACS analysis
To determine the significance of regulation of microRNA-34a and microRNA-194 by CEBPα during granulopoiesis in patients with acute myeloid leukemia with CEBPA mutations
To determine whether overexpression of micro RNA-34a and microRNA-194 in myeloid progenitors with CEBPα mutations leads to granulocytic differentiation
To examine how microRNA-34a and microRNA-194 downregulate E2F3 during granulopoiesis
To determine the role of microRNA-34a and microRNA-194 in myeloid cell proliferation
OUTLINE Cryopreserved cell samples are collected for laboratory analysis including mutation analysis gene expression analysis RNA analysis and fluorescence-activated cell sorting FACS analysis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NCI-2011-02207 | REGISTRY | CTRP Clinical Trial Reporting Program | None |
| COG-AAML10B13 | OTHER | None | None |
| CDR0000664229 | OTHER | None | None |