Ignite Creation Date:
2024-05-05 @ 10:11 PM
Last Modification Date:
2024-10-26 @ 10:15 AM
Study NCT ID:
NCT01056887
Status:
COMPLETED
Last Update Posted:
2011-04-25
First Post:
2010-01-25
Brief Title:
Copeptin in Differentiation of Polyuria and Polydipsia
Sponsor:
University of Wuerzburg
Organization:
University of Wuerzburg
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2010-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The differential diagnosis of patients with polyuria polydipsia is often complex but important for the therapeutic strategy
Challenging is in particular the clinical differentiation between patients with a partial Diabetes insipidus centralis and patients with primary polydipsia as underlying disease because both groups are associated with similar urinary osmolalities
The determination of plasma arginine vasopressin is unusual in this context since measurement of AVP is not reliably
C-terminal ProVasopressin copeptin is secreted stoichiometrically with AVP from the neurohypophysis but has a longer half life in the circulation and is thus easier to measure
Therefore the investigators will analyze in that study the diagnostic utility of plasma copeptin in the differential diagnosis of polyuria and polydipsia
Challenging is in particular the clinical differentiation between patients with a partial Diabetes insipidus centralis and patients with primary polydipsia as underlying disease because both groups are associated with similar urinary osmolalities
The determination of plasma arginine vasopressin is unusual in this context since measurement of AVP is not reliably
C-terminal ProVasopressin copeptin is secreted stoichiometrically with AVP from the neurohypophysis but has a longer half life in the circulation and is thus easier to measure
Therefore the investigators will analyze in that study the diagnostic utility of plasma copeptin in the differential diagnosis of polyuria and polydipsia
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 3307 | None | None | None |