Ignite Creation Date:
2024-05-05 @ 11:27 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00046605
Status:
COMPLETED
Last Update Posted:
2017-11-07
First Post:
2002-09-30
Brief Title:
Inflammation Genomics and Atherosclerosis - Ancillary to CARDIA
Sponsor:
University of Washington
Organization:
University of Washington
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2017-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine the associations of common variation in inflammationthrombosis genes with intermediate quantitative phenotypes and subclinical coronary atherosclerosis in the Coronary Artery Risk Factor Development in Young Adults CARDIA Study a large bi-racial cohort study
Detailed Description:
BACKGROUND
Atherosclerosis is a major determinant of coronary heart disease and is determined by the interplay of genetic and environmental risk factors Although atherosclerosis tends to aggregate in families it does not exhibit classical Mendelian segregation Thus the genes that determine an individuals risk of atherosclerosis likely involve multiple sites within genes and interactions between genes all of which define a genetic risk that is modified by the host environment
DESIGN NARRATIVE
The genetic epidemiology study examines the associations of common variation in inflammationthrombosis genes with intermediate quantitative phenotypes and subclinical coronary atherosclerosis in the Coronary Artery Risk Factor Development in Young Adults CARDIA Study a large bi-racial cohort study The set of 25 candidate genes involve pathways cytokines chemokines and their receptors cellular adhesion molecules and coagulation proteins and include several receptor-ligand pairs Using cladistic analysis and the resources of the Program in Genomic Applications PGA the investigators will identify a limited set of single nucleotide polymorphisms range 3-10 SNPs per gene that characterize common haplotypes in these candidate genes within persons of African descent and European descent DNA from the CARDIA Year 10 examination n 3950 subjects will be genotyped for the selected variants that characterize the common haplotypes Data on the presence of common variants and haplotypes will be incorporated into the CARDIA Study database Levels of two important intermediate phenotypes fibrinogen and C-reactive protein CRP were previously determined Non-invasive assessment of coronary atherosclerosis defined as the presence of coronary artery calcification CAC was obtained on CARDIA participants at the Year 15 exam Analyses will be stratified by raceethnicity and focus on the associations of the common haplotypes with fibrinogen CRP and CAC measured in early adult life Secondarily the investigators will explore possible gene-gene and gene-environment interactions The proposed multi-disciplinary collaboration should enhance the sensitivity and specificity of efforts to assess the associations of common variation in sets of inflammationthrombosis candidate genes and cardiovascular risk in young adults
Atherosclerosis is a major determinant of coronary heart disease and is determined by the interplay of genetic and environmental risk factors Although atherosclerosis tends to aggregate in families it does not exhibit classical Mendelian segregation Thus the genes that determine an individuals risk of atherosclerosis likely involve multiple sites within genes and interactions between genes all of which define a genetic risk that is modified by the host environment
DESIGN NARRATIVE
The genetic epidemiology study examines the associations of common variation in inflammationthrombosis genes with intermediate quantitative phenotypes and subclinical coronary atherosclerosis in the Coronary Artery Risk Factor Development in Young Adults CARDIA Study a large bi-racial cohort study The set of 25 candidate genes involve pathways cytokines chemokines and their receptors cellular adhesion molecules and coagulation proteins and include several receptor-ligand pairs Using cladistic analysis and the resources of the Program in Genomic Applications PGA the investigators will identify a limited set of single nucleotide polymorphisms range 3-10 SNPs per gene that characterize common haplotypes in these candidate genes within persons of African descent and European descent DNA from the CARDIA Year 10 examination n 3950 subjects will be genotyped for the selected variants that characterize the common haplotypes Data on the presence of common variants and haplotypes will be incorporated into the CARDIA Study database Levels of two important intermediate phenotypes fibrinogen and C-reactive protein CRP were previously determined Non-invasive assessment of coronary atherosclerosis defined as the presence of coronary artery calcification CAC was obtained on CARDIA participants at the Year 15 exam Analyses will be stratified by raceethnicity and focus on the associations of the common haplotypes with fibrinogen CRP and CAC measured in early adult life Secondarily the investigators will explore possible gene-gene and gene-environment interactions The proposed multi-disciplinary collaboration should enhance the sensitivity and specificity of efforts to assess the associations of common variation in sets of inflammationthrombosis candidate genes and cardiovascular risk in young adults
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL071017-05 | NIH | None | httpsreporternihgovquickSearchR01HL071017-05 |