Ignite Creation Date:
2025-12-24 @ 11:53 PM
Ignite Modification Date:
2025-12-25 @ 9:49 PM
Study NCT ID:
NCT07194551
Status:
RECRUITING
Last Update Posted:
2025-09-26
First Post:
2025-09-02
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnaire
Sponsor:
University of British Columbia
Organization:
Study Overview
Official Title:
Lynch Syndrome Carriers' Uterine Cancer Health Assessment: Sampling and DNA-based Detection
Status:
RECRUITING
Status Verified Date:
2025-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Lynch-SCAN
Brief Summary:
The goal of this study is to find out if self-collected vaginal swabs can be used to detect early signs of uterine cancer or related conditions in people with Lynch syndrome (LS) who still have their uterus. The study also tests if people with LS are willing and able to collect these samples themselves and whether they find the process acceptable.
The main questions this study asks are:
* Will people with LS take part in self-collection of vaginal samples, and do they find it acceptable?
* Can vaginal DNA mutations predict cancer risk or match results from other genetic or biopsy testing?
* Can a cancer risk model used in the general population also help identify risk in people with LS?
Participants will:
* Answer a health questionnaire about lifestyle and symptoms
* Collect their own vaginal swabs and measure their vaginal pH at home using a self-collection kit
* Complete short surveys around the time of self-collection and at the end of the study
The main questions this study asks are:
* Will people with LS take part in self-collection of vaginal samples, and do they find it acceptable?
* Can vaginal DNA mutations predict cancer risk or match results from other genetic or biopsy testing?
* Can a cancer risk model used in the general population also help identify risk in people with LS?
Participants will:
* Answer a health questionnaire about lifestyle and symptoms
* Collect their own vaginal swabs and measure their vaginal pH at home using a self-collection kit
* Complete short surveys around the time of self-collection and at the end of the study
Detailed Description:
None
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: