Ignite Creation Date:
2024-05-05 @ 11:27 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00042133
Status:
COMPLETED
Last Update Posted:
2015-04-14
First Post:
2002-07-24
Brief Title:
Socio-economic Status and Age-related Disability in a Biracial Community
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institute of Environmental Health Sciences NIEHS
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2015-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The overall goal of the proposed project is to examine the reasons for the higher levels of disability in older people of lower socio-economic status
Detailed Description:
This application is a continuation of an epidemiologic study that investigates the effect of socio-economic disadvantage and neighborhood conditions on disability in older blacks and whites The proposed project takes place in the context of a population-based longitudinal study of persons aged 65 years and over who live in a geographically defined urban biracial community area in Chicago During the initial funding period we have successfully collected yearly disability outcome data and detailed information on neighborhood conditions using self-report instruments and a systematic neighborhood survey of study area
The first overall goal of this continuation is to determine the relative contribution and specific nature of the neighborhood conditions that are associated with disability in older adults The second overall goal is to determine the biological mechanisms through which neighborhood conditions lead to increased disability focusing specifically on hyperactivity of the hypothalamus-pituitary-adrenal HPA axis via salivary cortisol and inflammatory processes via interleukin-6 IL-6 and C-reactive protein CRP obtained from blood samples To accomplish these goals we propose to continue yearly collection of disability outcome data and obtain blood samples and salivary cortisol from over 7000 participants These data will be integrated with a rich set of existing data on personal characteristics health conditions and neighborhood factors to test of series of specific hypotheses related to the overall goals
Disability is a common and highly prevalent consequence of age-related chronic diseases and a critical indicator of overall health among older people Prevention of disability is essential to improve the lives of older people and reduce health care costs The proposed work will contribute to a better understanding of the specific neighborhood conditions that are associated with increased disability laying the foundation for more effective policies to prevent disability in future generations of older adults
The first overall goal of this continuation is to determine the relative contribution and specific nature of the neighborhood conditions that are associated with disability in older adults The second overall goal is to determine the biological mechanisms through which neighborhood conditions lead to increased disability focusing specifically on hyperactivity of the hypothalamus-pituitary-adrenal HPA axis via salivary cortisol and inflammatory processes via interleukin-6 IL-6 and C-reactive protein CRP obtained from blood samples To accomplish these goals we propose to continue yearly collection of disability outcome data and obtain blood samples and salivary cortisol from over 7000 participants These data will be integrated with a rich set of existing data on personal characteristics health conditions and neighborhood factors to test of series of specific hypotheses related to the overall goals
Disability is a common and highly prevalent consequence of age-related chronic diseases and a critical indicator of overall health among older people Prevention of disability is essential to improve the lives of older people and reduce health care costs The proposed work will contribute to a better understanding of the specific neighborhood conditions that are associated with increased disability laying the foundation for more effective policies to prevent disability in future generations of older adults
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None