Ignite Creation Date:
2024-05-05 @ 11:27 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00042172
Status:
COMPLETED
Last Update Posted:
2014-03-03
First Post:
2002-07-24
Brief Title:
Treatment for Early Memory Loss
Sponsor:
University of Iowa
Organization:
University of Iowa
Study Overview
Official Title:
Cognitive Enhancers Explored With PET Imaging
Status:
COMPLETED
Status Verified Date:
2014-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to evaluate the effectiveness of donepezil Aricept for the treatment of mild cognitive impairment MCI in elderly adults This study will also determine whether adding ginkgo biloba extract GBE enhances the effects of donepezil
Detailed Description:
Cognition involves important thinking processes such as perception learning and reasoning There are currently no definitive treatments for cognitive deterioration This study focuses on elderly individuals with MCI because people at a pre-dementia stage may sustain the greatest and most lasting benefit from cognitive-enhancing agents
Patients receive either donepezil or placebo for the first 6 months of the study In the second 6 months of the study patients are randomized to receive either donepezil plus GBE or donepezil alone Positron Emission Tomography PET which provides a color-coded image of the brains blood flow in a particular area is used to assess brain activity during memory tasks A PET scan is performed at study entry 6 months and 1 year A vasodilator a drug that dilates the blood vessels is administered during the PET imaging procedure to determine whether vascular disease affects memory function A magnetic resonance imaging MRI scan is also taken to view the brain
Patients receive either donepezil or placebo for the first 6 months of the study In the second 6 months of the study patients are randomized to receive either donepezil plus GBE or donepezil alone Positron Emission Tomography PET which provides a color-coded image of the brains blood flow in a particular area is used to assess brain activity during memory tasks A PET scan is performed at study entry 6 months and 1 year A vasodilator a drug that dilates the blood vessels is administered during the PET imaging procedure to determine whether vascular disease affects memory function A magnetic resonance imaging MRI scan is also taken to view the brain
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DSIR AT-GP | US NIH GrantContract | None | httpsreporternihgovquickSearchR21MH061801 |
| R21MH061801 | NIH | None | None |