Ignite Creation Date:
2024-05-05 @ 10:09 PM
Last Modification Date:
2024-10-26 @ 10:14 AM
Study NCT ID:
NCT01041820
Status:
COMPLETED
Last Update Posted:
2019-11-25
First Post:
2009-12-30
Brief Title:
Critical Periods of Exercise
Sponsor:
University of Alabama at Birmingham
Organization:
University of Alabama at Birmingham
Study Overview
Official Title:
Critical Periods of Exercise
Status:
COMPLETED
Status Verified Date:
2019-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Early childhood 3-7 years of age is an important window for determining body composition trajectory and may be a critical period for the development of tissue partitioning patterns that influence obesity risk As adiposity accelerates during this critical period deposition preservation of fat stores may be sustained at the expense of other tissues ie energy homeostasis may be inherently biased toward fat gain The type and amount of tissue mass accrued in early childhood has implications for metabolic profile glucoseinsulin homeostasis hormone profile and resting energy expenditure
The interplay between fat and bone deposition represents a physiologic trait enabling the body to choose between shuttling energy towards accrual of a particular tissue Plausibly the phenotype underlying obesity and diabetes risk may be determined by the differentiation of cell type adipocyte osteocyte etc during this early stage of growth and development In vitro studies demonstrate transdifferentiation under the influence of specific external stimuli which can switch phenotypes toward other cell lineages Further rodent models have demonstrated that exposure to stimuli exercise early in life may prevent excess fat mass accrual in adulthood even when the stimulus is later removed animals are no longer exercising Childrens early experiences engagement in physical activity vs sedentary behavior may environmentally induce alterations in body composition and predispose individuals to obesity throughout life
Aim 1 To examine the associations between body composition via DXA and objectively-measured physical activityinactivity
1 Hypothesis 11 There is a positive association between physical activity and bone mass
2 Hypothesis 12 There is a positive association between sedentary behavior and total fat mass
Aim2 To examine the associations between adipose tissue distribution via MRI and objectively-measured physical activityinactivity
3 Hypothesis 21 There is an inverse association between physical activity and bone marrow adipose tissue
4 Hypothesis 22 There is a positive association between sedentary behavior and bone marrow adipose tissue
The interplay between fat and bone deposition represents a physiologic trait enabling the body to choose between shuttling energy towards accrual of a particular tissue Plausibly the phenotype underlying obesity and diabetes risk may be determined by the differentiation of cell type adipocyte osteocyte etc during this early stage of growth and development In vitro studies demonstrate transdifferentiation under the influence of specific external stimuli which can switch phenotypes toward other cell lineages Further rodent models have demonstrated that exposure to stimuli exercise early in life may prevent excess fat mass accrual in adulthood even when the stimulus is later removed animals are no longer exercising Childrens early experiences engagement in physical activity vs sedentary behavior may environmentally induce alterations in body composition and predispose individuals to obesity throughout life
Aim 1 To examine the associations between body composition via DXA and objectively-measured physical activityinactivity
1 Hypothesis 11 There is a positive association between physical activity and bone mass
2 Hypothesis 12 There is a positive association between sedentary behavior and total fat mass
Aim2 To examine the associations between adipose tissue distribution via MRI and objectively-measured physical activityinactivity
3 Hypothesis 21 There is an inverse association between physical activity and bone marrow adipose tissue
4 Hypothesis 22 There is a positive association between sedentary behavior and bone marrow adipose tissue
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None