Ignite Creation Date:
2024-05-05 @ 11:27 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00041860
Status:
COMPLETED
Last Update Posted:
2005-06-24
First Post:
2002-07-18
Brief Title:
Modulation of Benzene Metabolism by Exposure to Environment
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institute of Environmental Health Sciences NIEHS
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2002-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The research is to evaluate benzene metabolism after exposure at levels that can be found in the environment such as the higher end concentrations in the air inside cars and buses while being driven in heavy traffic and inside private and public parking garages To do so breath urine and blood samples prior to during and after being exposed to benzene as well as benzene levels and benzene metabolites present are measured
Detailed Description:
The research is to evaluate benzene metabolism after exposure at levels that can be found in the environment such as the higher end concentrations in the air inside cars and buses while being driven in heavy traffic and inside private and public parking garages To do so breath urine and blood samples prior to during and after being exposed to benzene as well as benzene levels and benzene metabolites present are measured The exposures take place in the Controlled Environmental Facility operated by the Environmental and Occupational Health Sciences Institute EOHSI This allows us to control the exact benzene air level and to use benzene containing 13C a stable non-radioactive form of carbon one of the atoms that make up benzene Isotopes are different forms of the same atom Using 13C will allow us to tell the difference between the benzene and the compounds it changes to in the body that come from our experiment compared to what is present in your body from other sources In addition to just benzene exposure on some days the subject is also be exposed to methyl tertiary butyl ether MTBE another component of gasoline to take an iron supplement pill andor to take vitamins C and E pills How benzene is metabolized or changed in the body will be compared for these differences to better understand how the body deals with benzene
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None