Ignite Creation Date:
2025-12-24 @ 11:51 PM
Ignite Modification Date:
2025-12-25 @ 9:45 PM
Study NCT ID:
NCT06180551
Status:
RECRUITING
Last Update Posted:
2023-12-22
First Post:
2023-12-12
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Homburg Renal Evaluation Study on the Clinical Utility of Early AKI Diagnosis
Sponsor:
Universität des Saarlandes
Organization:
Study Overview
Official Title:
Homburg Renal Evaluation Study on the Clinical Utility of Early AKI Diagnosis
Status:
RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RESCUE-AKI
Brief Summary:
Critically ill patients are at risk of developing a sudden decrease of kidney function which may be detected by a decrease in urine output or is diagnosed on the basis of blood tests for substances normally eliminated by the kidney, primarily creatinine.
Because it takes about 24 hours for the creatinine level to rise, even if both kidneys have ceased to function, better markers are needed.
This trial is investigating if the marker urinary dickkopf-3 (uDKK3) allows an early prediction of a sudden decrease of kidney function.
Because it takes about 24 hours for the creatinine level to rise, even if both kidneys have ceased to function, better markers are needed.
This trial is investigating if the marker urinary dickkopf-3 (uDKK3) allows an early prediction of a sudden decrease of kidney function.
Detailed Description:
Urinary dickkopf-3 (uDKK3), a stress-induced renal tubular epithelium-derived glycoprotein, has been identified as a biomarker predicting persistent kidney dysfunction.
In this prospective observational trial in patients at high risk of developing acute kidney injury we will assess whether urinary dickkopf-3 serves as a predictor of acute kidney injury.
Patients of the intensive care units of Saarland University Hospital will be surveyed for up to two years after their admission to the intensive care unit.
The progression of the estimated Glomerular Filtration Rate and uDKK3 will be monitored.
In this prospective observational trial in patients at high risk of developing acute kidney injury we will assess whether urinary dickkopf-3 serves as a predictor of acute kidney injury.
Patients of the intensive care units of Saarland University Hospital will be surveyed for up to two years after their admission to the intensive care unit.
The progression of the estimated Glomerular Filtration Rate and uDKK3 will be monitored.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: