Ignite Creation Date:
2024-05-05 @ 10:07 PM
Last Modification Date:
2024-10-26 @ 10:14 AM
Study NCT ID:
NCT01033175
Status:
COMPLETED
Last Update Posted:
2010-07-07
First Post:
2009-12-15
Brief Title:
The Impact of Anemia of Chronic Disease on Chronic Obstructive Pulmonary Disease Patients
Sponsor:
Aristotle University Of Thessaloniki
Organization:
Aristotle University Of Thessaloniki
Study Overview
Official Title:
The Clinical Impact of Anemia of Chronic Disease on Chronic Obstructive Pulmonary Disease Patients
Status:
COMPLETED
Status Verified Date:
2009-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hypothesis
The first part of the study is a survey on the prevalence of anemia of chronic disease ACD among COPD patients The 2nd and 3rd part will test 2 null hypotheses Ho 1serum inflammatory markers and plasma erythropoietin do not differ between COPD patients with and without ACD and 2 exercise capacity does not differ between COPD patients with and without ACD
Rationale-Aim
ACD is an immune driven disorder developing in subjects suffering from chronic inflammatory diseases COPD is a disorder very likely to be associated to ACD due to its systemic inflammatory dimension Currently data on the prevalence of ACD and on the level of inflammatory markers which are implicated in the pathogenesis of ACD in COPD subjects are limited and controversial Furthermore there is no data on the effect of ACD on exercise capacity of COPD subjects
Based to the aforementioned this study has three goals
1 to determine the prevalence and the epidemiologic characteristics of ACD in a population of clinical stable COPD patients
2 to investigate whether the levels of serum inflammatory markers and of plasma erythropoietin differ between COPD patients with ACD and without ACD
3 to determine potential differences regarding the aerobic exercise capacity between these two groups using the cardiopulmonary exercise testing CPET
The first part of the study is a survey on the prevalence of anemia of chronic disease ACD among COPD patients The 2nd and 3rd part will test 2 null hypotheses Ho 1serum inflammatory markers and plasma erythropoietin do not differ between COPD patients with and without ACD and 2 exercise capacity does not differ between COPD patients with and without ACD
Rationale-Aim
ACD is an immune driven disorder developing in subjects suffering from chronic inflammatory diseases COPD is a disorder very likely to be associated to ACD due to its systemic inflammatory dimension Currently data on the prevalence of ACD and on the level of inflammatory markers which are implicated in the pathogenesis of ACD in COPD subjects are limited and controversial Furthermore there is no data on the effect of ACD on exercise capacity of COPD subjects
Based to the aforementioned this study has three goals
1 to determine the prevalence and the epidemiologic characteristics of ACD in a population of clinical stable COPD patients
2 to investigate whether the levels of serum inflammatory markers and of plasma erythropoietin differ between COPD patients with ACD and without ACD
3 to determine potential differences regarding the aerobic exercise capacity between these two groups using the cardiopulmonary exercise testing CPET
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None